Cover; Contents; List of Contributors; Abbreviations and Symbols; Some Articles Planned for Future Volumes; Chapter 1. The -C-C-A End of tRNA and Its Role in Protein Biosynthesis; I . Introduction; II . Structure of the -N-C-C-A Terminus; III. Structure of Aminoacyl-tRNA; IV. Enzymic Modification of the 3' End of tRNA; V. Aminoacylation of tRNA; VI. Positional Specificity of Aminoacylation and Chemical ŽProofreadingŽ; VII. Binding of Aminoacyl-tRNA to Ribosomes; VIII. Ribosomal Peptidyltransferase Center; References; Chapter 2. The Mechanism of Action of Antitumor Platinum Compounds

I. IntroductionII. Chemical Features of Platinum Drugs; III. Biological Effects of Platinum Coordination Complexes Indicative of Reactions with DNA; IV. Biochemical Effects of Platinum Complexes Indicative of Reactions with DNA; V. Interaction of Platinum Compounds with DNA; VI. Repair of DNA Damage Induced by Platinum Complexes in Vivo; VII. Concluding Remarks; References; Chapter 3. DNA Glycosylases, Endonucleases for Apurinic/Apyrimidinic Sites, and Base Excision-Repair; I. Introduction; II. Models for Excision-Repair of DNA; III. DNA Glycosylases

IV. Endonucleases for Apurinic/Apyrimidinic Sites (AP Endonucleases)V. Repair of Apurinic Sites in DNA by Alternative Pathways; References; Chapter 4. Naturally Occurring Nucleoside and Nucleotide Antibiotics; Introduction; I. Inhibitors of Protein Synthesis; II. Inhibitors of RNA Synthesis; III. Inhibitors of DNA Synthesis, DNA Viruses, and RNA Viruses; IV. Inhibitors of Adenosine Deaminase and Effectors of the Immune Response; V. Inhibitors of Cell- Wall Synthesis and Antifungal Agents; VI. Inhibitors of Purine and Pyrimidine lnterconversions; VII. Hyperesthetic and Hyperemic Agents

VIII. Cyclic-AMP Phosphodiesterase InhibitorsIX. Miscellaneous Naturally Occurring Nucleosides; References; Chapter 5. Genetically Controlled Variation in the Shapes of Enzymes; I. Introduction; II. Internal Standardization; III. The Interaction of Protein Size and Charge during Electrophoresis; IV. Detecting ""Hidden"" Variation in Shape; V. The Nature of Cryptic Variants; VI. Major Unresolved Issues: Posttranslational Modification; VII. Novel Approaches to Electrophoresis; References; Chapter 6. Transcription Units for mRNA Production in Eukaryotic Cells and Their DNA Viruses

I. IntroductionII . Techniques for Defining Transcription Units; III. Definition of Transcription Units for mRNA; IV. The Precursor Relationship of Large Nuclear Primary Transcripts to mRNA; V. Recent Evidence on the Formation of mRNA from Primary Transcripts; VI. Models for the Regulation of Eukaryotic Gene Expression; VII. Conclusion; References; Note Added In Proof; Index; Contents of Previous Volumes