Drug Therapy: The Impact of Managed Care; The Role of Phosphodiesterase Enzymes in Allergy and Asthma; Modulating Protein Kinase C Signal Transduction; Preventive Role of Renal Kallikrein-Kinin System in the Early Phase of Hypertension and Development of New Antihypertensive Drugs; The Multienzyme PDE4 Cyclic Adenosine Monophosphate-Specific Phosphodiesterase Family: lntracellular Targeting, Regulation, and Selective Inhibition by Compounds Exerting Anti-inflammatory and Antidepressant Actions; Clinical Pharmacology of Systemic Antifungal Agents: A Comprehensive Review of Agents in Clinical Use, Current Investigational Compounds, and Putative Targets for Antifungal Drug Development.