Glycosaminoglycan (GAG) Biosynthesis and GAG-Binding Proteins -- Mice Deficient in Glucuronyltransferase-I -- Mice Deficient in Heparan Sulfate N-Deacetylase/N-Sulfotransferase 1 -- Glucuronyl C5-Epimerase -- Mice Deficient in Heparan Sulfate 6-O-Sulfotransferase-1 -- The Roles of Chondroitin-4-Sulfotransferase-1 in Development and Disease -- Roles of Heparan Sulfate in Mammalian Brain Development: Current Views Based on the Findings from Ext1 Conditional Knockout Studies -- Anticoagulant Heparan Sulfate -- Endothelial Heparan Sulfate in Angiogenesis -- Hepatic Heparan Sulfate Proteoglycans and Endocytic Clearance of Triglyceride-Rich Lipoproteins -- Serglycin Proteoglycan Deletion in Mouse Platelets: Physiological Effects and Their Implications for Platelet Contributions to Thrombosis, Inflammation, Atherosclerosis, and Metastasis -- Congenital Disorders of Glycosylation with Emphasis on loss of Dermatan-4-Sulfotransferase -- Heparan Sulfate Proteoglycans in Amyloidosis -- Heparin as an Inhibitor of Cancer Progression -- Diverse Functions of Glycosaminoglycans in Infectious Diseases -- Molecular Mechanism Underlines Heparin-Induced Thrombocytopenia and Thrombosis -- Chondroitin Sulfate and Abnormal Contact System in Rheumatoid Arthritis -- Activated Contact System and Abnormal Glycosaminoglycans in Lupus and other Auto- and Non-Autoimmune Diseases -- Glycosaminoglycans and Activated Contact System in Cancer Patient Plasmas.