Defining the role of pharmacology in the emerging world of translational research / S.J. Enna and M. Williams -- Anti-inflammatory agents as cancer therapeutics / Khosrow Kashfi -- The development and pharmacology of proteasome inhibitors for the management and treatment of cancer / Bruce Ruggeri [and others] -- Subtype-selective GABA(subscript A) receptor modulation yields a novel pharmacological profile: the design and development of TPA023 / John R. Atack -- New approaches for the treatment of sleep disorders / Nicholas A. DeMartinis, Jayesh Kamath, and Andrew Winokur -- Current and emerging strategies for treating dyslipidemia and macrovascular disease / Jerry R. Colca and Rolf F. Klerzien -- Discovery of drugs to treat cocaine dependence: behavioral and neurochemical effects of atypical dopamine transport inhibitors / Gianluigi Tanda, Amy H. Newman, and Jonathan L. Katz -- Novel strategies and targets for the management of hypertension / David A. Taylor and Abdel A. Abdel-Rahman -- New approaches to the pharmacological management of major depressive disorder / Jeffrey M. Witkin and Xia Li -- Preclinical behavioral models for predicting antipsychotic activity / Vincent Castagné, Paul C. Moser, and Roger D. Porsolt -- New developments in the therapy of pulmonary fibrosis / Alexander Scriabine and Daniel U. Rabin.