I. History -- The history of Neuroimmune Biology: -- II. Cytokines and in the brain; -- A. Cytokines, their receptors and signal transduction in the brain; -- Cytokine Receptors in the Brain; -- Interleukin-1 and Corticotropin Releasing Factor Receptors in the Hypothalamic-Pituitary-Adrenal Axis; -- Brain interleukin-1́ expression and action in the absence of neuropathology; -- Interleukin 1́ signal transduction via the sphingomyelin pathway in brain cells; -- Blood-brain barrier transport of cytokines; -- B. Cytokines in brain physiology -- Cytokines in synaptic function; -- Interleukin-2 as a Neuroregulatory Cytokine; -- Cytokines and Extracellular Matrix Remodeling in the Central Nervous System; -- Acidic fibroblast growth factor, a satiety substance, variegated physiological significance; -- Cytokines and Sleep; -- -- C. Chemokines in the brain; -- Chemokines, their receptors and significance in brain function; -- IV. Immune response in the brain; -- Immune and inflammatory responses in the CNS: modulation by astrocytes; -- Immune Response in the Brain: Glial Response and Cytokine Production; -- V. Cytokines in pathophysiological brain responses; -- A. Brain-immune interaction -- Lymphocytes and adrenergic sympathetic nerve system: the role of cytokines; -- Cytokines in Neural Signaling to the Brain; -- Interleukin-2 gene expression in CNS cells after stress and antigen application; -- Sex hormones and cytokines in CNS pathology and repair; -- Involvement of brain cytokines in stress-induced immunosuppression; -- Neuroprotective Effects of Inflammation in the Nerves System; -- VI. Disease; -- Brain Response to Endotoxin; -- Cytokines in Demyelinating Disease; -- The Cytokines and Depression Hypothesis: An Evaluation; -- Clinical Relevance: Cytokines in Alzheimer's Disease; -- VII. Cytokines and behaviour; -- Cytokines and immune-related behaviors; -- The production and effects of cytokines depend on brain lateralization.