Cover -- Copyright page -- List of Contributors -- Preface -- Contents -- Section I: Fever and Hyperthermia -- Chapter 1. The onset of fever: new insights into its mechanism -- Introduction -- Pyrogen activation of the brain: the role of the vagus -- PGE2, not cytokines, is the peripheral fever trigger -- Contribution of preoptic PGE2 to fever production -- Conclusions -- Acknowledgments -- References -- Chapter 2. Eicosanoids in non-febrile thermoregulation -- Introduction -- Prostaglandins -- Leukotrienes and other lipoxygenase products of AA -- Conjugates of AA -- Conclusions -- Abbreviations -- Acknowledgments -- References -- Section II: Physiological Mechanisms in Hyperthermia -- Chapter 3. Exercise and heat stress: cerebral challenges and consequences -- Introduction: the hot and hard working brain -- Central fatigue and critical internal temperatures -- Cerebral thermodynamic responses during exercise -- Cerebral blood flow and metabolism -- Neurohumoral responses in relation to hyperthermia-induced fatigue -- Conclusions -- Abbreviations -- References -- Chapter 4. Neuropsychological determinants of exercise tolerance in the heat -- Introduction -- Neuropsychological responses to hyperthermia -- Heat stress countermeasures -- Summary -- Acknowledgments -- References -- Section III: Drugs and Hyperthermia -- Chapter 5. Thermophysiological responses to hyperthermic drugs: extrapolating from rodent to human -- Introduction -- Thermoregulatory profile and hyperthermic efficacy of drugs -- Ambient temperature and potential hyperthermic response -- Patterns of drug toxicity as function of temperature -- Extrapolating from rodent to human -- Methylenedioxymethamphetamine (MDMA) -- Interaction between hyperthermia and drug toxicity -- Reactive oxygen species (ROS) -- Conclusions -- Acknowledgements -- References -- Chapter 6. Neuroleptic malignant syndrome and serotonin syndrome -- Introduction -- Neuroleptic malignant syndrome -- Serotonin syndrome -- References -- Section IV: Therapeutic Hyperthermia and Consequences -- Chapter 7. Radio frequency electromagnetic fields: mild hyperthermia and safety standards -- Introduction -- Dosimetry of radio frequency electromagnetic fields -- Thermoregulation2 -- Behavioral effects of RF-EMF exposure -- Basis of safety standards -- Conclusions -- Disclaimer -- References -- Chapter 8. The effect of induced hyperthermia on the immune system -- Introduction -- Basic effects of hyperthermia -- Effects of heat on the immune system -- Lymphocyte apoptosis as part of immune regulation and putative effect of therapeutical hyperthermia -- Conclusion -- References -- Chapter 9. Cerebral pathophysiology and clinical neurology of hyperthermia in humans -- Introduction -- Therapeutic hyperthermia in humans -- Fever in neurologically injured patients -- Conclusions -- Abbreviations -- References -- Section V: Hyperthermia and Brain Pathology -- Chapter 10. Methods to produce hyperthermia-induced brain dysfunction -- Introduction -- Model of whole-body hyperthermia -- Conclusion -- Acknowledgments --T$1.