Epidemiology -- Genetics and Proteomics -- Immunopathogenesis -- Viruses -- Etiopathogenic role of B-cells -- Oral involvement -- Ocular involvement -- Ear, nose and throat involvement -- Fatigue, fibromyalgia and other general symptoms -- Musculoskeletal involvement -- Non-vasculitic cutaneous involvement -- Vasculitis -- Cardiovascular involvement -- Pulmonary involvement -- Raynaud phenomenon -- Gastrointestinal involvement -- Autoimmune liver involvement -- Pancreatic involvement -- Nephro-urological involvement -- Central nervous system involvement -- Peripheral neuropathy -- Autonomic neuropathy -- Endocrine involvement -- Gynecological and obstetrical complications -- Laboratory abnormalities -- Diagnostic procedures (I) -- Diagnostic procedures (II) -- Immunological tests -- Classification criteria -- Measurement of chronicity and activity -- Measurement of quality of life -- Association with other autoimmune and rheumatic diseases -- Cancer -- Prognostic factors and survival -- SS in primary care.-Treatment of sicca features -- Treatment of B-cell lymphoma -- Classic immunosuppressive and immunomodulatory drugs -- New immunosuppressive and immunomodulatory drugs -- B-cell targeted therapies -- Other biological therapies -- Experimental therapies.