Section 1. Introduction -- 1. Mechanisms of Gastrointestinal Carcinogenesis -- Section 2. Epithelial Neoplastic Disease -- 2. Targeted Therapies and Molecular Diagnostics of Gastrointestinal Cancers -- 3. Molecular Pathology of Barrett's Metaplasia and Esophageal Adenocarcinoma -- 4. Molecular Pathology of Squamous Carcinomas of the Esophagus -- 5. Molecular Mechanisms and Pathology of Gastric Carcinogenesis: Sporadic Cancers -- 6. Hereditary Diffuse Gastric Cancer and Other Gastric Cancers Associated with Hereditary Predisposition Syndromes -- 7. Cancer Predisposition Syndromes of the Gastrointestinal Tract -- 8. Molecular Pathology of Colon and Small Bowel Cancers: Sporadic Types -- 9. Cancers of the Rectum and Anal Canal -- 10. Molecular Pathology of Inflammatory Bowel Disease Associated Neoplasia -- Section 3. Non-Epithelial Neoplastic  Tumors -- 11. Molecular Biology and Pathology of Gastrointestinal Stromal Tumors -- 12. Neuroendocrine Tumors -- Section 4. Metastatic Disease and Tumor Markers -- 13. Molecular Mechanisms of Tumor Metastases -- 14. Circulating Tumor Cells and Nucleic Acids for Tumor Diagnosis -- 15. Serological Markers of Digestive Tract Cancers.