Patients who suffer from the biological, genetic, epigenetic neurocognitive dysfunction and social sequela of substance use disorders and addiction require the empowering support from healthcare professionals; necessitating the need to utilize an ethics of care to re-interpret consent for the management of care for those who suffer from substance use disorders and addiction. The care of the 'other' should embrace a care paradigm that is relational and collaborative in order to eliminate constructs of stigma, moral weakness and individual blame, which isolates those who manifest the trajectory of harms associated with addiction pathology. Relational consent and an ethics of care seeks to enhance the relational decision-making processes for those who experience the complications from this stress surfeit and executive cognitive functioning disorder. The re-interpretation of consent seeks to improve patient outcomes, improve quality of healthcare delivery and enhance human dignity for vulnerable populations.