Cover; Contents; Contributors to This Volumes; Chapter 1. Screening for and Evaluation of Anticoccidial Activity; I. Introduction; II. Screening in Embryos or Tissue Culture; III. Screening in the Chicken; IV. Cage Evaluation Experiments; V. Drug Resistance Studies; VI. Point and Type of Action Studies; VII. Conclusions; References; Chapter 2. Information Services of the International Cancer Research Data Bank (ICRDB) Program in Cancer Chemotherapy and Pharmacology; I. Introduction; II. Collection of Data; III. ICRDB Data Bases for Cancer Researchers

IV. Searching of Cancer Data Bases and Indexing of Biomedical InformationV. Publications Used to Disseminate Cancer-Related Information Automatically; VI. Scientist-to-Scientist Communication Projects; Reference; Chapter 3. Dihydrofolate Reductase: Binding of Substrates and Inhibitors and Catalytic Mechanism; I. Introduction; II. Critical Aspects of the Enzyme Structure; III. Physicochemical Aspects; IV. Biochemical Aspects; V. Folate Biochemistry; VI . Antifolate Pharmacology; References

Chapter 4. Distribution and Classification of Airway Histamine Receptors: The Physiological Significance of Histamine H2-ReceptorsI. Introduction; II. Airway Histamine Receptor Distribution and Classification; III. Mechanisms of Action of Histamine on Airway Smooth Muscles; IV. Modulatory Roles of Histamine H2-Receptors; V. Summary and Conclusions; References; Chapter 5. In Vitro Methods to Predict for Patient Response to Chemotherapy; I. Introduction; II. Requirements for in Vitro Systems; III. General Technical Problems for in Vitro Systems; IV. Specific in Vitro Predictive Tests

V. SummaryReferences; Chapter 6. Macrophage Activation for Nonspecific Tumor Cytotoxicity; I. Introduction; II. Pathways for Induction of Activated Macrophages; III. Mechanisms of the Cytotoxic Action of Activated Macrophages; IV. Naturally Occurring Inhibitors of Cytotoxic Activity; V. Therapeutic Considerations; VI. Concluding Remarks; References; Chapter 7. Prenatal and Neonatal Toxicology and Pathology of Heavy Metals; I. General Concept on Teratogenesis; II. Toxic Effects of Mercury on Development; III. Toxic Effects of Cadmium on Development; IV. Toxic Effects of Lead on Development

V. Concluding RemarksReferences; Chapter 8. Salicylates: Molecular Mechanism of Therapeutic Action; I. General Aspects; II. Special Aspects; III. General Summary and Conclusions; References; Chapter 9. Physiological and Pharmacological Determinants of Sensitivity and Resistance to 5-Fluorouracil in Lower Animals and Man; I. Introduction; II. Preclinical Studies; III. Clinical Studies; IV. Summary and Prospects; References; Index