Front Cover; Advances in Applied Microbiology, Volume 21; Copyright Page; Contents; List of Contributors; Chapter 1. Production of Polyene Macrolide Antibiotics; I. Introduction; II. Factors Affecting Polyene Macrolide Production; III. Interaction of Polyene Macrolide Antibiotics with the Producer Cells; IV. Genetics of Polyene-Producing Streptomyces; References; Chapter 2. Use of Antibiotics in Agriculture; I. Introduction; II. Agricultural Antibiotics and the Pollution Problem; III. Utilization of Medical Antibiotics as Agricultural Chemicals

IV. Antibiotics Developed as Agricultural ChemicalsV. Future Prospects; References; Chapter 3. Enzymes Involved in ß-Lactam Antibiotic Biosynthesis; I. Introduction; II. Structure of ß-Lactam Antibiotics; III. Biosynthesis Mechanisms of ß-Lactam Antibiotics and Their Enzymes; IV. Terminal-Stage Enzyme Reactions in ß-Lactam Antibiotic Biosynthesis; V. Concluding Remarks; References; Chapter 4. Information Control in Fermentation Development; I. Introduction; II. Research and Development Budget; III. Project Initiation Request (Research or Development Program); IV. Formal Program

V. Periodical ReportsVI. Laboratory and Plant Protocols; VII. The Standard Operating Procedure; VIII. Direct Experimental Records; IX. Miscellaneous Information by Memoranda; X. Minutes; XI. Collection and Flow of Information; XII. Making the Best Use of Data; References; Chapter 5. Single-Cell Protein Production by Photosynthetic Bacteria; I. Introduction; II. Process Considerations; III. Conceptual Design; IV. Economic Analysis; References; Chapter 6. Environmental Transformation of Alkylated and Inorganic Forms of Certain Metals; I. Introduction

II. Biochemical, Photochemical, and Chemical Transformation of Metals and MetalloidsIII. Test Methods for Studying Transformation; IV. Analytical Procedures; V. Factors Affecting Transformation of Metals; VI. Biochemical Pathways and Mechanisms for Transformation of Metals; VII. General Discussion of Various Test Methods; VIII. Correlation between Laboratory and Field Results and Monitoring Data; IX. Restoration of Metal-Contaminated Areas; X. Categorization of Elements; XI. Summary and Conclusions; References

Chapter 7. Bacterial Neuraminidase and Altered Immunological Behavior of Treated Mammalian CellsI. Introduction; II. Neuraminidase-The Receptor-Destroying Enzyme; III. Sialic Acid and Its Relationship to the Antigenicity of the Cell Surface; IV. Increased Immunogenicity of Neuraminidase-Treated Cells; V. Regression of Established Solid-Tissue Tumor; VI. How Do Neuraminidase-Treated Tumor Cells React in the Host to Establish Specific Antitumor Immunity?; VII. A Probable Mechanism by Which Neuraminidase-Treated Tumor Cells Give Rise to Specific Antitumor Immunity; VIII. Summary; References