Front Cover; Advances in Immunology, Volume 45; Copyright Page; Contents; Chapter 1. Cellular Interactions in the Humoral Immune Response; I. Introduction; II. Antigen Processing and Presentation; III. Helper T Cells; IV. Physical Interaction between T and B Cells; V. Interleukins; VI. Cellular Interactions in Vivo-A Synthesis; References; Chapter 2. MHC-Antigen Interaction: What Does the T Cell Receptor See?; I. Introduction; II. The T Cell Receptor and Accessory Molecules; III. The MHC Molecules; IV. The Processed Antigen; V. The Questionable Homogeneity of Individual MHC Molecules.

VI. MHC-Antigen InteractionsVII. Structural Data on T Cell Epitopes; VIII. Alloreactivity; IX. Do TcRs See Polymorphic (Haplotype-Specific) Residues of MHC Molecules?; X. Relevance to the Ontogeny of the T Cell Repertoire; References; Chapter 3. Synthetic T and B Cell Recognition Sites: Implications for Vaccine Development; I. Introduction; II. Immunological Considerations; III. Enumeration and Functional Characteristics of T Cell Recognition Sites Defined by Synthetic Peptides; IV. Enumeration of B Cell Recognition Sites Defined by Synthetic Peptides.

V. Methods of Predicting T and B Cell Recognition SitesVI. Status of Candidate Synthetic Peptide Vaccines; VII. Conclusions; References; Chapter 4. Rationale for the Development of an Engineered Sporozoite Malaria Vaccine; I. Introduction; II. Sporozoite-Induced Immunity to Malaria; III. Properties of CS Proteins; IV. Role of Antibodies in Protection; V. Interferon-? Affects the Liver Stages; VI. The Need for CS-Specific T Cells in Sporozoite Vaccines; VII. Human Trials of Sporozoite Vaccines.

VIII. Relationship between Immunity to Malaria in Endemic Areas and the Presence in Serum of Antibodies to NANPnIX. Vaccination with P. vivax CS Protein; X. Perspectives; References; Chapter 5. Virus-Induced Immunosuppression: Infections with Measles Virus and Human Immunodeficiency Virus; I. Introduction; II. Measles Virus; III. Human Immunodeficiency Virus and Immunosuppression; IV. Conclusion; References; Chapter 6. The Regulators of Complement Activation (RCA) Gene Cluster; I. Introduction; II. The Complement Pathways; III. Biochemical Interactions of the RCA Proteins with C3b/C4b.

IV. The Roles of the RCA ProteinsV. The Short Consensus Repeat: Structure and Function; VI. Variations in Structure and Expression of the RCA Proteins; VII. Organization and Evolution of the RCA Genes; VIII. Utilization of RCA-Like Proteins by Human Pathogens; IX. Conclusion; References; Chapter 7. Origin and Significance of Autoreactive T Cells; I. Introduction; II. Origin; III. Activation Requirements and Specificity; IV. Physiological Significance; V. Regulation; VI. Conclusion; References; Index; Contents of Recent Volumes.