Front Cover; Idiotypes; Copyright Page; Table of Contents; PREFACE; Part I: Structure-Function Relationships in Idiotypes; CHAPTER 1. THE GAT SYSTEM: A POSSIBLE GERM LINE IDIOTYPIC NETWORK1; INTRODUCTION; THE GAT MODEL; CONCLUSIONS; ACKNOWLEDGMENTS; REFERENCES; CHAPTER 2. THE GERM LINE VH AND DH GENE SEGMENTS ENCODING THE ARS A FAMILY OF ANTI-ARSONATE ANTIBODIES; HEAVY CHAIN VARIABLE REGION GENE SEGMENTS OF THE ARS A FAMILY; THE DFL16.1 GENE SEGMENT OF THE A/J STRAIN; THE ""N"" SEGMENT OF ARS-A ANTIBODIES; CONCLUSION; ACKNOWLEDGMENTS; REFERENCES

CHAPTER 3. GENERATION OF ANTIBODY DIVERSITY IN THE PC-SPECIFIC IMMUNE RESPONSE TO PROTEUS MORGANII1MATERIALS AND METHODS; RESULTS AND DISCUSSION; REFERENCES; Part II: Auto-Anti-Idiotypes and Regulation of the Immune Response; CHAPTER 4. REGULATION OF ANTIBODY CLONES IN RABBITS BY AUTO-ANTI-IDIOTYPE1; INTRODUCTION; AUTO-ANTI-IDIOTYPIC ANTIBODIES: ARTIFICIAL INDUCTION; AUTO-ANTI-IDIOTYPIC ANTIBODIES: NATURAL OCCURRENCES; CONCLUDING COMMENTS; REFERENCES; CHAPTER 5. A REGULATORY IDIOTYPE ON AUTOANTIBODIES1; INTRODUCTION; MATERIALS AND METHODS; RESULTS; DISCUSSION; ACKNOWLEDGEMENTS; REFERENCES

CHAPTER 6. IDIOTYPE NETWORK REGULATION: ANALYSIS OF MECHANISMS USING A PLASMACYTOMA MODEL1INTRODUCTION; EFFECT OF ANTI-IDIOTYPIC ANTIBODIES ON MOPC-315 CELLS; INHIBITION OF SYNTHESIS AND SECRETION OF M315 BY MOPC-315 CELLS; SUMMARY AND CONCLUDING REMARKS; ACKNOWLEDGMENTS; REFERENCES; CHAPTER 7. REGULATION OF ANTI-DNA ANTIBODIES BY ANTI-IDIOTYPIC ANTIBODIES IN SERA OF FAMILIES OF LUPUS PATIENTS1; INTRODUCTION; MATERIALS AND METHODS; RESULTS; DISCUSSION; REFERENCES; Part III: Internal Images and the Immune Network; CHAPTER 8. FROM IDIOTYPES TO IDIOTYPIC NETWORKS1; FOREWORD; INTRODUCTION