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Handbook of mucosal immunology
Title:
Handbook of mucosal immunology
Author:
Ogra, Pearay L.
Publication Information:
San Diego : Academic Press, ©1994.
Physical Description:
1 online resource (xxi, 766 pages) : illustrations
Contents:
Cellular basis of mucosal immunity -- Development and physiology of mucosal defense -- Structure and function of intestinal mucosal epithelium -- Cellular and molecular basis for antigen transport in the intestinal epithelium -- Mucosal barrier -- Innate humoral factors -- Bacterial adherence and mucosal immunity -- Mucosal immunoglobulins -- Phylogenetic aspects of mucosal immunoglobulins -- Developmental aspects of mucosal immunoglobulin genes -- Epithelial and hepatobiliary transport of polymeric immunoglobulins -- Function of mucosal immunoglobulins -- Cells, regulation and specificity in the mucosal immune system: inductive sites -- Characteristics and functions of mucosa-associated lymphoid tissue -- Peyer's patches as inductive sites for IgA commitment -- Regulation of IgA B cell development -- Diversity and function of antigen-presenting cells in mucosal tissues -- Oral tolerance and regulation of immunity to dietary antigens.
(cont) Oral tolerance and regulation of immunity to dietary antigens -- Functional aspects of the peptidergic circuit in mucosal immunity -- Role of B-1 cells in mucosal immune responses -- Lymphocyte homing to mucosal effector sites -- Cells, regulation, specificity in the mucosal immune system: effector sites -- Normal state -- Cytokines in the mucosal immune system -- Distribution and characteristics of mucosal immunoglobulin-producing cells -- T helper cells for mucosal immune responses -- Human gastrointestinal mucosal T cells -- Basic aspects of intraepithelial lymphocyte immunobiology -- Mucosal immunity and inflammation -- IgE-mediated responses in the mucosal immune system -- Inflammation: mast cells -- Cytokines in the liver and gastrointestinal tract -- Cytotoxic lymphocytes in mucosal effector sites -- Mucosal immunity to viruses -- Mucosal immunization and vaccines -- Passive immunization -- Common mucosal immune system and strategies for the development of vaccines effective at the mucosal surfaces.
(cont) Antigen delivery systems -- Mucosal adjuvants -- Monoclonal secretory IgA for protection of the intestinal mucosa against viral and bacterial pathogens -- Mucosal diseases -- Stomach, intestine and liver -- Gut-associated lymphoid tissue -- Alpha chain disease and related lymphoproliferative disorders -- Gastritis and peptic ulcer -- Role of the mucosal immune system in ulcerative colitis and Crohn's disease -- Malabsorption syndromes and intestinal protein loss -- Food allergy -- Intestinal infections -- Liver and biliary tract -- Lungs and airways -- Bronchial mucosal lymphoid tissue -- Mucosal immune function in asthma -- Respiratory infections -- Inhalant allergy and hypersensitivity disorders -- Oral cavity, upper airway and head and neck -- Ocular mucosal immunity -- Mucosal immunology of the middle ear and eustachian tube -- Immunology of diseases of the oral cavity -- Immunobiology of the tonsils and adenoids -- Mammary glands -- Immunological components of milk.
(cont) Immunologic effects of breast-feeding on the infant -- Genitourinary tract -- IgA nephropathy and related diseases -- Mucosal immunity in the female and male reproductive tracts -- Immunologically mediated male and female reproductive failure -- Endocrine regulation of mucosal immunity -- Mucosal immunopathophysiology of HIV infection -- Genital tract infection.
Abstract:
Researchers have recently made tremendous progress in the area of mucosal immunology, greatly increasing our understanding of the common mucosal immune system, mucosal infections, and oral immunization. However, thisresearch has not previously been made available in a single work. In its large 81/2"x 11"format, Handbook of Mucosal Immunology covers the entire spectrum of mucosal immunity and is organized in two main sections to present the basic biology of the common mucosal immune system and the immune responses of the mucosae. The first section provides an introduction and historical perspective of the mucosal immune system and includes comprehensive discussion of the development and physiology of mucosal defense. It discusses such topics as the structure and function of themucosal epithelium, characteristics of mucosal-associated lymphoid tissue (MALT), Peyers patches, and concepts of mucosal vaccines. The second section focuses on the secretory immune system with special reference to mucosal diseases in the digestive (GALT), respiratory (BALT), and genitourinary tracts. This information is especially important in light of the current interest in the mechanisms, transmission, and prevention of infectious diseases such as AIDS, hepatitis, and tuberculosis. Virtually all chapters have been authored by the original investigators responsible for key observations on which current concepts are based. This handbook will be an invaluable resource for a diverse group of both researchers and practicing clinicians. Molecular biologists, immunologists, veterinarians, public health workers, physicians in specialties from pediatrics to pulmonology, and graduate students of mucosal immunology will all find this handbook the most complete work on the subject.
Genre:
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Electronic Access:
ScienceDirect http://www.sciencedirect.com/science/book/9780125247306 ScienceDirect https://www.sciencedirect.com/science/book/9780125247306Available:*
Shelf Number | Item Barcode | Shelf Location | Status |
|---|---|---|---|
| QR185.9 .M83 M84 1994 | 1177334-1001 | Elsevier E-Book Collections | Searching... |
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