Front Cover; Ordering the Membrane-Cytoskeleton Trilayer; Copyright Page; Contents; Contributors; Foreword; Preface; Previous Volumes in Series; Chapter 1. Molecular Genetic Analyses of Drosophila Kinesin; I. Introduction; II. Kinesin Structure; III. Kinesin Function; IV. Conclusion; References; Chapter 2. Acanthamoeba Myosin I: Past, Present, and Future; I. Discovery; II. Multiplicity of Isoforms; III. Heavy Chain Sequences; IV. Structural Basis of the Actin-Activated ATPase Activity; V. Mechanochemical Properties and Their Structural Basis; VI. Regulation; VII. Intracellular Localization

VIII. Concluding RemarksReferences; Chapter 3. Structural and Functional Dissection of a Membrane-Bound Mechanoenzyme: Brush Border Myosin I; I. Introduction: Is There a Superfamily of Myosin Genes?; II. The Structural and Functional Properties of Brush Border Myosin I: An Overview; III. Probing the Function of Brush Border Myosin I Calmodulin Light Chains; IV. The Interaction of Brush Border Myosin I with the Microvillar Membrane; V. Some Notions Regarding Brush Border Myosin I Function; References; Chapter 4. Protein Interactions Linking Actin to the Plasma Membrane in Focal Adhesions

I. IntroductionII. Interaction between a-Actinin and ß1 Integrin; III. Interaction between Talin and Actin; IV. Conclusion; References; Chapter 5. Ankyrins: A Family of Proteins That Link Diverse Membrane Proteins To the Spectrin Skeleton; I. Introduction; II. Ankyrin Structure; III. Ankyrins Are a Multigene Family; IV. Functional Diversity of Ankyrin due to Alternative Splicing of mRNA; V. Mapping the Binding Sites of Ankyrin; VI. Summary and Future Perspectives; References; Chapter 6. Contractile and Cytoskeletal Proteins in Drosophila Embryogenesis; I. Introduction

II. Movements of Early EmbryogenesisIII. Cell Shape Change Requires Remodeling of the Actin Cytoskeleton; IV. Non-Muscle Myosins; V. Spectrins; VI. Summary; References; Chapter 7. Dominant Mutations of Cytoskeletal Proteins in Xenopus Embryos; I. Introduction; II. The Role of Membrane Skeleton Protein 4.1 during Embryogenesis; III. Dissecting the Functions of Vimentin during Embryonic Development; IV. Discussion; References; Chapter 8. The Animal Models of Duchenne Muscular Dystrophy: Windows on the Pathophysiological Consequences of Dystrophin Deficiency; I. Introduction

II. The Animal Models of Duchenne Dystrophy: Biochemical and Genetic HomologyIII. Human Duchenne Dystrophy: Progressive Histopathology Leading to Muscle Wasting; IV. The mdx Mouse: Nonprogressive Histopathology Resulting in Hypertrophy; V. The xmd Dog: Rapidly Progressive Histopathology Leading to Muscle Wasting; VI. The Dystrophin-Deficient Cat: Semiprogressive Histopathology with No Loss of Muscle Fibers; VII. Phase I. The Primary Cellular Consequence of Dystrophin Deficiency: Generalized Leakage of the Plasma Membrane Buffered by the Syncytial Cytoplasm?