Front Cover; Progress in Medicinal Chemistry, Volume 4; Copyright Page; Contents; Preface; Chapter 1. Experimental Hypersensitivity Reactions; Introduction; Studies on histamine; Studies on 5-hydroxytryptamine; Studies on bradykinin; The anaphylactoid reaction; Influence of the adrenal gland; Influence of the thyroid gland; Influence of insulin; Discussion; Chapter 2. Mechanisms of Toxic Action; Introduction; Biochemical basis of some toxic actions; Interpretation of biochemical disturbances; Research into toxic mechanisms; General aspects of drug toxicity; Conclusions

Chapter 3. Drug Receptor InteractionsIntroduction; The drug; The receptor; Drug receptor interactions: the forces; Drug receptor interactions: the consequences; Chapter 4. Polypeptides of Medicinal Interest; Introduction; Techniques of Peptide chemistry; Methods of structural elucidation; Methods of peptide synthesis; Polypeptides; Method of presentation; Oxytocin and vasopressin; Corticotropin and the melanocyte-stimulating hormones; Angiotensin; Bradykinin and kallidin; Insulin and glucagon

Chapter 5. Analgesics and Their Antagonists: Biochemical Aspects and Structure-Activity RelationshipsEstimation of analgesics in biological media; Absorption, distribution and excretion of analgesics; Metabolism of analgesics; Antagonists of analgesics; Relation of morphine-type analgesics to adrenergic and cholinergic mechanisms and other biochemical processes; Structure-activity relationships; Index