Front Cover; Immunological Approaches to Embryonic Development and Differentiation; Copyright Page; Contents; List of Contributors; Preface; Chapter 1. The Use of Monoclonal Antibody Techniques in the Study of Developing Cell Surfaces; I. Introduction; II. The Hybrid Myeloma Technique and the Production and Use of Monoclonal Antibodies; III. Use of Monoclonal Antibodies to Define Differentiation Antigens of Cells of the Immune System and to Characterize Their Subsets; IV. Other Systems; V. Future Prospects; VI. Concluding Remarks; References; Chapter 2. Early Stages of Lymphocyte Development

I. Organization of the Lymphoid System: OverviewII. Hemopoiesis: Definitions and Basic Considerations; III. Hemopoietic Stem Cells; IV. Thymocyte Progenitor Cells; V. Thymocytopoiesis; VI. Concluding Remarks; References; Chapter 3. Somatic Cell Genetics and the Development of the Immune System; I. The Major Components of the Immune System; II. Somatic Cell Genetics; III. Applications of Somatic Cell Genetics to the Analysis of the Immune System; IV. Concluding Remarks; References

Chapter 4. Complete Primary Structure of Human Histocompatibility Antigen HLA-B7: Evolutionary and Functional ImplicationsI. Introduction; II. Purification of HLA-A and -B Antigens after Papain Solubilization; III. Dissection of the Papain-Solubilized Heavy Chain into Three Regions by Chemical Cleavages; IV. Complete Primary Sequence of Papain-Solubilized HLA-B7; V. Sequence Homology to Immunoglobulin Sequences; VI. Purification of HLA-A and -B Antigens after Detergent Solubilization; VII. Structure of the Penultimate Hydrophobic and C-Terminal Hydrophilic Peptides

VIII. Use of HLA-A and -B Antigens Reconstituted in Liposomes to Study FunctionIX. Concluding Remarks; References; Chapter 5. Aspects of Surface Membrane Differentiation during Maturation of Human Hematopoietic and Tumor Cells: The La System; I. Demonstration of Ia on Leukemic Granulocyte Membrane; II. Occurrence of Ia Determinants on Myeloid Cells from Normal Bone Marrow; III. Expression of Receptors for Complement and IgG Fc; IV. Presence of Ia on Megakaryocytes; V. Ia Expression on Hematopoietic Progenitor Cells; VI. Presence of Ia on Certain Cultured Malignant Melanoma Cells

VII. Concluding RemarksReferences; Chapter 6. The ABH Blood Groups and Development; I. Introduction; II . The ABH Substances; III . The Distribution of the ABH Antigens in the Body; IV . Function and Biological Significance of ABH Antigend/Substances; V . The ABH Antigens in Feto-Maternal Relationships; VI . Concluding Remarks; References; Chapter 7. Cell-Mediated Immune Responses to Mouse Embryonic Cells: Detection and Characterization of Embryonic; I . Introduction; II . Some Cell Surface Antigens of Early Mouse Embryos; III . Cell-Mediated Immune Responses to Early Mouse Embryos