Front Cover; Progress in Molecular Biology and Translational Science; Copyright Page; Contents; Contributors; Preface; Introduction: Regulatory Mechanisms in Transcriptional Signaling by Nuclear Hormone Receptors, and their Regulators: Implications in Physiology and Disease; Acknowledgment; B. PPARgamma; C. LXR and Atherosclerosis; F. Therapeutic Potential of LXR Ligands; A. FXR and the Control of Bile Metabolism; E. FXR and Diabetes; G. Therapeutic Potential of FXR Ligands; V. RORalpha; E. Therapeutic Potential of ERRalpha Ligands

Chapter 2: Progesterone Receptor Action in Leiomyoma and Endometrial CancerB. Progesterone Receptors; D. Progesterone Receptors in the Endometrium and Myometrium; B. Progesterone Receptors in Endometrial Cancer; C. Growth Factor Regulation in Leiomyoma by Progesterone; IX. Conclusions and Perspectives on Progesterone Action in Uterine Leiomyoma; I. Introduction; 1. PXR in UGT Regulation; 2. PXR in SULT Regulation; 3. PXR in GST Regulation; 1. PXR in Bile Acid Detoxification and Cholestasis; 2. PXR in Bilirubin Detoxification and Clearance

3. PXR in Adrenal Steroid Homeostasis and Drug-Hormone Interactions4. PXR in Lipid Metabolism; G. Species Specificity of PXR and the Creation of ``Humanized ́ ́ Mice; 1. Challenges for Rodents as Drug Metabolism Models; 2. Species Specificity of the Rodent and hPXR; 3. Creation and Characterization of the hPXR ''Humanized'' Mice; 4. Significance of Humanized Mice in Drug Metabolism Studies and Drug Development; 1. CAR Regulation of CYP2C Genes; 2. CAR Regulation of UGT1A1 Genes; 3. CAR Regulation of Drug Transporters; Acknowledgments

A. Nuclear Receptor Protein Stability, Targeting by the Ubiquitin Proteasome System and Influences of Ligand on Nuclear Receptor Protein DegradationB. Role of the Ubiquitin Proteasome System in Nuclear Receptor-Mediated Transcription; II. Biochemical Analyses of NR Activities, Interactions, and Functions: An Historical View; A. Elucidation of NR Biochemical Activities; D. Transcriptional Regulation by NRs: Early Studies; III. Role of Chromatin in NR-Dependent Transcription; A. Chromatin: The Physiological Template for NR-Dependent Transcription; B. Linking NR Function to Chromatin

B. DNA TemplatesC. Methods for Assembling Chromatin In Vitro; 1. Salt Dilution/Dialysis Chromatin Assembly Systems; 2. Extract-Based Chromatin Assembly Systems; 3. Defined Chromatin Assembly Systems; 1. Nuclease Digestion of Chromatin Assembled In Vitro; 2. Analysis of the Physical Properties of Chromatin Assembled in vitro; 3. Imaging of Chromatin Assembled in vitro; A. Role of Ligands; 1. Agonist Ligands are Required for NR-Dependent Transcription with Chromatin Templates; 2. Agonist Ligands Promote Productive Interactions with NR Coregulators; 1. p160/SRC Proteins