Front Cover; Progress in Nucleic Acid Research and Molecular Biology, Volume 42; Copyright Page; Contents; Abbreviations and Symbols; Some Articles Planned for Future Volumes; Chapter 1. The Trp Repressor, A Ligand-Activated Regulatory Protein; I. Early (Pre-cloning) Research on the Trp Repressor, 1959-1980; II. The Molecular Cloning of trpR+ DNA Opened the Floodgates to Structure-Function Analysis; III. Nucleotide Sequence of trpR DNA; IV. Autogenous Transcriptional Regulation of the trpR Gene; V. Signal Strength of the trpR Promoter Relative to Other s70 Promoters of E. coli

VI. Translation of trpR mRNA and the Effect of Temperature on Regulation in the trp SystemVII. The Primary Amino-acid Sequence of the Trp Repressor: General Overview; VIII. Engineered Systems for Overproduction of the Trp Repressor; Protein Purification Schemes; IX. Interaction of Tryptophan and Its Analogs with the Trp Repressor; Effects of Ligand Binding on Operator Affinity; X. Operator Targets Recognized by the Trp Holorepressor; XI. Structural Alterations in Trp Repressor Generated by Mutation or Proteolysis

XII. The Trp Repressor as a Prototypical Member of Helix-turn-helix Family of DNA-Binding ProteinsXIII. Concluding Comments and Perspectives for Future Research on the Trp Repressor; References; Chapter 2. lmmunochemical Analyses of Nucleic Acids; I. Sources and Assays of Antibodies to Nucleic Acids; II. Antibodies to B-DNA; III. Antibodies to Single-stranded DNA; IV. Antibodies to Z-DNA; V. Variants of Double-stranded DNA: Poly(dA)·poly(dT) and "Bent" DNA; VI. Triplex DNA; VII. Antibodies to RNA·DNA; VIII. Branched-chain Ribonucleic Acid; IX. Cruciform DNA

X. Antibodies to Modified Nucleosides and Nucleotides: BromodeoxyuridineXI. Antibodies to Alkylated Nucleic Acids; XII. Summary and Future Prospects; References; Chapter 3. Oligodeoxynucleotides as Antisense Inhibitors of Gene Expression; I. Oligonucleotides as Informational Drugs; II. Phosphorothioate Oligodeoxynucleotides; III. Inhibition of Translation in Cell-free Systems; IV. Cellular Uptake; V. Oncogene Inhibition; VI. Other Oligodeoxynucleotide Analogs; VII. Other Approaches; VIII. Conclusion; References

Chapter 4. 5,6-Dihydropyrimidine Adducts in the Reactions and Interactions of Pyrimidines with ProteinsI. Approaches to Detect Michael Adducts of Pyrimidines; II. Enzyme Systems That Form Michael Adducts; References; Note Added in Proof; Chapter 5. RNA Replication of Plant Viruses Containing an RNA Genome; I. Overview; II. Replication of Brome Mosaic Virus RNA; III. Replication of Cowpea Chlorotic Mottle Virus RNA; IV. Replication of Cucumber Mosaic Virus RNA; V. Replication of Alfalfa Mosaic Virus RNA; VI. Replication of Turnip Yellow Mosaic Virus RNA