The unusual history and unique properties of the calcium signal / Ernesto Carafoli -- The evolution of the biochemistry of calcium / Robert J.P. Williams -- Calcium-binding proteins and the EF-hand principle / Joachim Krebs and Claus W. Heizmann -- Structural aspects of calcium-binding proteins and their interactions with targets / Peter B. Stathopulos, James B. Ames, and Mitsuhiko Ikura -- Voltage-gated calcium channels, calcium signaling, and channelopathies / Erika S. Piedras-Renteria, Curtis F. Barrett, Yu-Qing Cao, and Richard W. Tsien -- Exchangers and Ca² signaling / Joachim Krebs -- The plasma membrane calcium pump / Claudia Ortega, Saida Ortolano, and Ernesto Carafoli -- Endoplasmic reticulum dynamics and calcium signaling / Allison Kraus and Marek Michalak -- Structual aspects of ion pumping by Ca²-ATPase of sarcoplamic reticulum / Chikaski Toyoshima -- Ca²/Mn² pumps of the Golgi apparatus and Hailey-Hailey disease / Leonard Dode, Jo Vanoevelen, Ludwig Missiaen, Luc Raeymaekers, and Frank Wuytack -- IP₃ receptors and their role in cell function / Katsuhiko Mikoshiba -- Ryanodine receptor structure, function and pathophysiology / Spyros Zissimopoulos and F. Anthony Lai -- The calcium/calmodulin-dependent protein kinase cascades / Felice A. Chow and Anthony R. Means -- The Ca²-calcineurine-NFAT signalling pathway / Stefan Feske, Anjana Rao, and Patrick G. Hogan -- Temporal and spatial regulation of calcium-dependent transcription / Jacob Brenner, Natalia Gomez-Ospina, and Ricardo Dolmetsch -- Calcium and fertilization / Jong Tai Chun and Luigia Santella -- Ca² signaling during embryonic cytokinesis in animal systems / Sarah E. Webb and Andrew L. Miller -- Mitochondrial Ca² and cell death / Tullio Pozzan and Rosario Rizzuto -- Calcium signalling, a spatiotemporal phenomenon / Michael John Berridge.