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Functional genomics and proteomics in the clinical neurosciences
Title:
Functional genomics and proteomics in the clinical neurosciences
Author:
Hemby, S. E., editor.
ISBN:
9780080465630
9780444518538
Edition:
1st edition.
Physical Description:
1 online resource (x, 317 pages) : illustrations (some color)
Series:
Progress in brain research, volume 158
Progress in brain research ; v. 158.
Contents:
Section I: Methodologies -- Tissue preparation and banking -- Functional genomic methodologies -- Methods for proteomics in neuroscience -- Functional genomics and proteomics in the clinical neurosciences: data mining and bioinformatics -- Reproducibility of microarray studies: concordance of current analysis methods -- Introduction -- Section II: Applications of Genomics and Proteomic Technologies to Clinical Neuroscience -- The genomics of mood disorders -- Assessment of genome and proteome profiles in cocaine abuse -- Neuronal gene expression profiling: uncovering the molecular biology of neurodegenerative disease -- Epileptogenesis-related genes revisited -- Functional genomics of sex hormone-dependent neuroendocring systems: specific and generalized actions in the CNS -- Section III: Future Directions -- Implications for the practice of psychiatry -- Human brain evolution.
Abstract:
The purpose of this work is to familiarize neuroscientists with the available tools for proteome research and their relative abilities and limitations. To know the identities of the thousands of different proteins in a cell, and the modifications to these proteins, along with how the amounts of both of these change in different conditions would revolutionize biology and medicine. While important strides are being made towards achieving the goal of global mRNA analysis, mRNA is not the functional endpoint of gene expression and mRNA expression may not directly equate with protein expression.
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Electronic Access:
ScienceDirect https://www.sciencedirect.com/science/bookseries/00796123/158 ScienceDirect https://www.sciencedirect.com/science/book/9780444518538 ScienceDirect https://www.sciencedirect.com/science/publication?issn=00796123&volume=158Available:*
Shelf Number | Item Barcode | Shelf Location | Status |
|---|---|---|---|
| RC455.4 .G4 F86 2006 EB | 1181689-1001 | Elsevier E-Book Collections | Searching... |
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