Front Cover -- Molecular Action of Toxins and Viruses -- Copyright Page -- Table of Contents -- Editors foreword -- List of contributors -- Chapter 1. Diphteria toxin; biological activity, by Tsuyoshi Uchida -- 1. Introduction -- 2. Biosynthesis of diphtheria toxin -- 3. Inhibition of protein synthesis by diphtheria toxin -- 4. Entry of diphtheria toxin into cells -- 5. Concluding remarks -- References -- Chapter 2. Cholera toxin action and the regulation of hormonesensitive adenylate cyclase, by Gary L. Johnson -- 1. Introduction

2. Regulation of hormone-sensitive adenylate cyclase3. Action of cholera toxin on adenylate cyclase -- 4. Future uses of cholera toxin -- Acknowledgments -- References -- Chapter 3. Toxic lectins and related proteins, by Sjur Olsnes and Alexander Pihl -- 1. Introduction -- 2. Purification of toxic lectins -- 3. Structure and physical properties -- 4. Toxicity -- 5. Mechanism of action -- 6. Hybrid toxins -- 7. Cell agglutination and lymphocyte stimulation -- 8. Uses in protein and cell fractionation and characterization -- 9. Anticancer properties

10. Concluding remarksAcknowledgments -- References -- Chapter 4. Bacterial cytolysins (membrane-damaging toxins), by J.P. Arbuthnott -- 1. Introduction -- 2. Phospholipases -- 3. Thiol-activated cytolysins -- 4. Staphylococcal a-toxin -- 5. Staphylococcal d-toxin -- 6. Concluding remarks -- References -- Chapter 5. The mechanism of action of colicin E2, Colicin E3 and Cloacin DF13, by Karen S. Jakes -- 1. Introduction -- 2. Colicin E3 and cloacin DF13 -- 3. Colicin E2

4. Structure-function relationships for colicins E2 and E3 and cloacin DF13: molecular topography5. Possible role of in vivo cleavage of colicin or cloacin in biological activity -- 6. Model for lethal action of colicins E2 and E3 and cloacin DF13 on sensitive cells -- Acknowledgments -- References -- Chapter 6. Similarities in the action of different toxins, by Simon van Heyningen -- 1. Proteins with a binding component and an active component -- 2. ADP-Ribosylation -- 3. Binding to ganglioside -- Acknowledgments -- References

Chapter 7. The role of cell membranes in infection with bacterial viruses and colicins, by Manfred Schweiger and Monica Hirsch-Kauffmann1. Introduction -- 2. The action of colicins on membranes -- 3. The interactions of bacterial viruses with cell membranes -- 4. Conclusions -- Acknowledgments -- References -- Chapter 8. Bacteriophage T4 infection mechanisms, by Diet mar Rabussay -- 1. General introduction -- 2. T4 and the other T-bacteriophages -- 3. The T4 genome -- 4. Growth cycle -- 5. Infection