Recent advances in Parkinson's disease
Title:
Recent advances in Parkinson's disease
Author:
Björklund, Anders, 1945-
ISBN:
9780444536143
9781282879997
9781282880047
Publication Information:
Amsterdam : Elsevier, 2010.
Physical Description:
1 online resource (xii, 320 pages) : illustrations.
Series:
Progress in brain research, v. 183
Progress in brain research ; v. 183.
Contents:
Progress in Brain Research; Copyright; List of Contributors; Preface; Contents; Section I. Genetic and molecular mechanisms of neurodegeneration in PD; Chapter 1. Identifying PD-causing genes and genetic susceptibility factors: current approaches and future prospects; Abstract; Keywords; Introduction; Identification of monogenic forms of PD by positional cloning strategies; Autosomal-recessive parkinsonism; Rare genetic variants causing or pre-disposing to PD; Future strategies; Conclusion; Abbreviations; References
Chapter 2. The impact of genetic research on our understanding of Parkinson's diseaseAbstract; Keywords; Introduction; Dominantly inherited mutations; Conclusion; Acknowledgements; Abbreviations; Chapter 3. Unravelling the role of defective genes; Abstract; Keywords; Introduction; Summary; Acknowledgements; Abbreviations; References; Chapter 4.What causes the death of dopaminergic neuronsin Parkinson's disease?; Abstract; Pan-cellular risk factors in Parkinson's disease; Cell-specific risk factors in PD; Do other types of neuron that succumb in PD share these risk factors?
Is there an interaction between risk factors?Can dihydropyridines be therapeutically effective?; Epidemiological support for cell-specific riskfactors; Unanswered questions; Conclusions; Abbreviations; References; Chapter 5. Intracellular signalling pathways in dopamine cell death and axonal degeneration; Abstract; Keywords; PCD in dopamine neurons: major pathways of neuron destruction; Intracellular signalling pathways for dopa minergicaxonal degeneration; PCD in dopamine neurons: is it only downstream?; PCD in dopamine neurons: is it the default mode?; Summary and conclusions
AcknowledgementsAbbreviations; References; Chapter 6. Control of mitochondrial integrity in Parkinson's disease; Abstract:; Keywords; Mitochondrial fusion and fission machinery; Mitochondrial motility; Mitophagy; Conclusions; Acknowledgement; Abbreviations; References; Chapter 7. Role of post-translational modifications in modulating the structure, function and toxicity a-synuclein: implications for Parkinson's disease pathogenesis and therapies; Abstract; Keywords; Introduction; Structural and biochemical properties of a-syn
The rate of a-synuclein fibrillization is affected by several factors that may be relevant to PDPhosphorylation; Truncations; Ubiquitination; Conclusions; Abbreviations; References; Section IICellular and system-level pathophysiologyof the basal ganglia in PD; Chapter 8. The role of dopamine in modulating the structure and function of striatal circuits; Abstract; Keywords; Introduction; Acute dopaminergic modulation of striatal MSN excitability; LTD at glutamatergic synapses on MSNs; LTP at glutamatergic synapses on MSNs; Dendritic excitability and synaptic plasticity
Abstract:
This first volume starts with an overview on current perspectives in genetic research and on the molecular mechanisms of neurodegeneration. This is followed by a selection of hot topics in pathophysiological research, from molecular studies to system-level investigations based on in vivo electrophysiological recordings and neurocomputational methods. Complete overview of hot topics and approaches to current PD research, from molecules, to brain circuits, to clinical and therapeutic applications. Leading authors review the state-of-the-art in their field of investigation, and provide their views and perspectives for future research. All chapters include comprehensive background information and are written in a clear form that is accessible also to the non-specialist.
Genre:
Electronic Access:
ScienceDirect http://www.sciencedirect.com/science/book/9780444536143 https://www.sciencedirect.com/science/bookseries/00796123/183Available:*
Shelf Number | Item Barcode | Shelf Location | Status |
|---|---|---|---|
| RC382 .R43 2010 EB | 1183256-1001 | Elsevier E-Book Collections | Searching... |
On Order
Select a list
Make this your default list.
The following items were successfully added.
There was an error while adding the following items. Please try again.
:
Select An Item
Data usage warning: You will receive one text message for each title you selected.
Standard text messaging rates apply.