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Essential concepts in molecular pathology
Title:
Essential concepts in molecular pathology
Author:
Coleman, William B.
ISBN:
9780123744180
9781282954090
9780080922188
9786612954092
Publication Information:
Amsterdam ; Boston : Elsevier/Academic Press, ©2010.
Physical Description:
1 online resource (xxi, 440 pages) : illustrations (chiefly color)
Contents:
Cover13; -- Essential Concepts in Molecular Pathology -- Copyright Page -- Dedication -- Contents -- List of Contributors -- Preface -- Foreword -- Acknowledgements -- Part I: Essential Pathology -- Mechanisms of Disease -- Chapter 1: Molecular Mechanisms of Cell Death -- Introduction -- Modes of Cell Death -- Structural Features of Necrosis and Apoptosis -- Cellular and Molecular Mechanisms Underlying Necrotic Cell Death -- Pathways to Apoptosis -- Mitochondria -- Nucleus -- Endoplasmic Reticulum -- Lysosomes -- Concluding Remark -- Acknowledgments -- Key Concepts -- Suggested Readings -- Chapter 2: Acute and Chronic Inflammation Induces Disease Pathogenesis -- Introduction -- Leukocyte Adhesion, Migration, and Activation -- Acute Inflammation and Disease Pathogenesis -- Pattern Recognition Receptors and Inflammatory Responses -- Chronic Inflammation and Acquired Immune Responses -- Tissue Remodeling During Acute and Chronic Inflammatory Disease -- Key Concepts -- Suggested Readings -- Chapter 3: Infection and Host Response -- Microbes and Hosts-Balance of Power? -- The Structure of the Immune Response -- Regulation of Immunity -- Pathogen Strategies -- The African Trypanosome and Antibody Diversity: Dueling Genomes -- Staphylococcus Aureus: the Extracellular Battleground -- Mycobacterium Tuberculosis and the Macrophage -- Herpes Simplex Virus: Taking Over -- HIV: The Immune Guerilla -- Perspectives -- Key concepts -- Suggested Readings -- Chapter 4: Neoplasia -- Introduction -- Cancer Statistics and Epidemiology -- Classification of Neoplastic Diseases -- Characteristics of Benign and Malignant Neoplasms -- Clinical Aspects of Neoplasia -- Key Concepts -- Suggested Readings -- Part II: Concepts in Molecular Biology and Genetics -- Chapter 5: Basic Concepts in Human Molecular Genetics -- Introduction -- Molecular Structure of DNA -- Modes of Inheritance -- Central Dogma and Rationale for Genetic Testing -- Allelic Heterogeneity and Choice of Analytical Methodology -- Conclusion -- Key Concepts -- Suggested Readings -- Chapter 6: The Human Genome -- Introduction -- Structure and Organization of the Human Genome -- Overview of the Human Genome Project -- Impact of the Human Genome Project on the Identification Of Disease-Related Genes -- Sources of Variation in the Human Genome -- Types of Genetic Diseases -- Genetic Diseases and Cancer -- Perspectives -- Key Concepts -- Suggested Readings -- Chapter 7: The Human Transcriptome -- Introduction -- Gene Expression Profiling: The Search for Candidate Genes Involved in Pathogenesis -- Transcriptome Analysis Based on Microarrays: Technical Prerequisites -- Microarrays: Applications in Basic Research and Translational Medicine -- Perspectives -- Key concepts -- Suggested readings -- Chapter 8: The Human Epigenome -- Introduction -- Epigenetic Regulation of the Genome -- Genomic Imprinting -- Cancer Epigenetics -- Human Disorders Associated with Epigenetics -- Key Concepts -- Suggested Readings -- Chapter 9: Clinical Proteomics and Molecular Pathology -- Understanding Cancer at the Molecular Level: An Evolving Frontier -- Microdissection Technology Brings Molecular Analysis to the Tissue Level -- Serum Proteomics: an Emerging Landscape.
Abstract:
This streamlined "essential" version of the Molecular Pathology (2009) textbook extracts key information, illustrations and photographs from the main textbook in the same number and organization of chapters. It is aimed at teaching students in courses where the full textbook is not needed, but the concepts included are desirable (such as graduate students in allied health programs or undergraduates). It is also aimed at students who are enrolled in courses that primarily use a traditional pathology textbook, but need the complementary concepts of molecular pathology (such as medical students). Further, the textbook will be valuable for pathology residents and other postdoctoral fellows who desire to advance their understanding of molecular mechanisms of disease beyond what they learned in medical/graduate school. Offers an essential introduction to molecular genetics and the "molecular" aspects of human diseaseTeaches from the perspective of "integrative systems biology," which encompasses the intersection of all molecular aspects of biology, as applied to understanding human diseaseIn-depth presentation of the principles and practice of molecular pathology: molecular pathogenesis, molecular mechanisms of disease, and how the molecular pathogenesis of disease parallels the evolution of the disease using histopathology. "Traditional" pathology section provides state-of-the-art information on the major forms of disease, their pathologies, and the molecular mechanisms that drive these diseases. Explains the practice of "molecular medicine" and the translational aspects of molecular pathology: molecular diagnostics, molecular assessment, and personalized medicineStudent web site hosts "self-assessment" questions; Professor web site hosts all figures from bookEach chapter ends with Key Summary Points and Suggested Readings.
Genre:
Electronic Access:
ScienceDirect http://www.sciencedirect.com/science/book/9780123744180Available:*
Shelf Number | Item Barcode | Shelf Location | Status |
|---|---|---|---|
| RB113 .E847 2010 EB | 1183331-1001 | Elsevier E-Book Collections | Searching... |
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