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Biothermodynamics. Part C
Title:
Biothermodynamics. Part C
Author:
Johnson, Michael L., 1947-
ISBN:
9780123812681
Edition:
1st ed.
Publication Information:
Amsterdam [Netherlands] ; Boston [Mass.] : Elsevier/Academic Press, 2011.
Physical Description:
1 online resource (xlv, 354 pages, 8 unnumbered pages of plates) : illustrations (some color).
Series:
Methods in enzymology, v. 488
Methods in enzymology ; v. 488.
Contents:
Measurement and analysis of equilibrium binding titrations : a beginner's guide / Macromolecular competition titration method : accessing thermodynamics of the unmodified macromolecule-ligand interactions through spectroscopic titrations of fluorescent analogs / Analysis of PKR-RNA interactions by sedimentation velocity / Structural and thermodynamic analysis of PDZ-ligand interactions / Thermodynamic analysis of metal ion-induced protein assembly / Thermodynamic dissection of colicin interactions / Energetics of Src homology domain interactions in receptor tyrosine kinase-mediated signaling / Structural and functional energetic linkages in allosteric regulation of muscle pyruvate kinase / Analysis of free energy versus temperature curves in protein folding and macromolecular interactions / Application of the sequential n-step kinetic mechanism to polypeptide translocases / A coupled equilibrium approach to study nucleosome thermodynamics / Quantitative methods for measuring DNA flexibility in vitro and in vivo
Abstract:
The use of thermodynamics in biological research can be equated to an energy book-keeping system. While the structure and function of a molecule is important, it is equally important to know what drives the energy force. This volume presents sophisticated methods for estimating the thermodynamic parameters of specific protein-protein, protein-DNA and small molecule interactions. Elucidates the relationships between structure and energetics and their applications to molecular design, aiding researchers in the design of medically important molecules.
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Electronic Access:
ScienceDirect http://www.sciencedirect.com/science/book/9780123812681 ScienceDirect http://www.sciencedirect.com/science/bookseries/00766879/488 ScienceDirect http://www.sciencedirect.com/science/publication?issn=00766879&volume=488Available:*
Shelf Number | Item Barcode | Shelf Location | Status |
|---|---|---|---|
| QP517 .T48 | 1183343-1001 | Elsevier E-Book Collections | Searching... |
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