Front Cover; Progress in Molecular Biology and Translational Science: The Brain as a Drug Target; Copyright; Contents; Contributors; Preface; Chapter 1: Monoamine Transporters: Vulnerable and Vital Doorkeepers; I. Introduction; II. Clinical Benefits: Demonstration of the Medical Roles of Monoamine Transporters; III. Preclinical Indications-Behavioral Pharmacology; IV. Molecular Study: cDNA Cloning and Structure Activity Relationship; V. Protein Regulations; VI. Animal Genetics; VII. The Transporter Genes as Risk Factors; VIII. Perspectives for Medication Development; Acknowledgments

VI. Future Directions for Optimization of Treatment RegimensReferences; Chapter 4: Insulin, Synaptic Function, and Opportunities for Neuroprotection; I. Introduction; II. Insulin Within the Central Nervous System; III. Insulin Receptors Within the Brain; IV. Insulin Signaling and Synaptic Function; V. Therapeutic Opportunities: Insulin and Neuroprotection; VI. General Summary; References; Chapter 5: Molecular Alterations in Glioblastoma: PotentialTargets for Immunotherapy; I. Introduction; II. Genetic Alterations in Glioblastoma; III. Ags and Biomarkers in Glioblastoma

IV. Ag-Specific Immunotherapy for GlioblastomaV. Biomarker-Specific Chemotherapy for Glioblastoma; VI. Cytokine-Based Immunotherapy for Glioblastoma; VII. Chemoimmunotherapy for Glioblastoma; VIII. Tumor-Associated Molecules Influencing Glioblastoma Immunotherapy; IX. Conclusions; Acknowledgments; References; Chapter 6: Molecular Signaling and Translational Significance of the Corticotropin Releasing Factor System; I. Introduction to the Corticotropin Releasing Factor Peptide Family; II. Neural CRF Distribution; III. CRF Binding and Signal Transduction

IV. Genes and Gene Systems Activated by CRFV. Interactions with Other Neural Circuits; VI. Translational Significance of CRF; VII. Integrated CRF Function; References; Chapter 7: Molecular Targets of Alcohol Action: Translational Research for Pharmacotherapy Development and Screening; I. Introduction; II. Alcohol Abuse and Dependence, Significance, and Treatment Needs; III. Preclinical Strategies for Identification of Novel Targets of Alcohol Action; IV. Translational Strategies and Need for Continued Biomarkers Development; References