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Activins and inhibins
Title:
Activins and inhibins
Author:
Litwack, Gerald.
ISBN:
9780123859624
9780123859617
Publication Information:
Amsterdam ; Boston : Elsevier/AP, 2011.
Physical Description:
1 online resource (xviii, 349 pages) : illustrations (some color).
Series:
Vitamins and hormones ; v. 85
Vitamins and hormones ; v. 85.
Contents:
Front Cover; Vitamins and Hormones: Activins and Inhibins; Copyright; Contents; Contributors; Preface; Chapter 1: Activin Receptor-Like Kinase and the Insulin Gene; I. Introduction; II. TGF-beta Family Receptors: ALK; III. Activin Isoforms A, B, and AB; IV. Nodal; V. Insulin Gene Regulation; VI. Conclusion; Acknowledgments; References; Chapter 2: Crystal Structure of Activin Receptor Type IIB Kinase Domain; I. Introduction; II. Type I Receptor Kinase Domain Structures; III. 3D Structure of ActRIIB; IV. Conclusion; References; Chapter 3: Activin/Nodal Signaling and Pluripotency
I. IntroductionII. Conclusion; References; Chapter 4: Intracrine Signaling Mechanisms of Activin A and TGF-beta; I. Common TGF-beta and Activin A Signaling and Target Genes: Focusing on CTGF/CCN2; II. The Early Response to Cellular Stress: Intracellular Activation of TGF-beta; III. Continuous Low-Level Activation of Activin A/TGF-beta Target Genes; IV. Intracrine Signaling: General Aspects; V. Intracrine Signaling of TGF-beta: The Stimulatory Pathway; VI. Intracrine Signaling of TGF-beta: The Inhibitory Pathway; VII. Intracrine Activin A Signaling; VIII. Conclusion; References
Chapter 5: Negative Regulation of Activin Signal TransductionI. Introduction; II. Extracellular Antagonists; III. Negative Regulation of Activin Receptor Function; IV. Inhibitory Smads; V. Interfering with Smad Function; VI. Negative Regulation of Gene Transcription; VII. Conclusions; Acknowledgments; References; Chapter 6: Antagonism of Activin by Activin Chimeras; I. Introduction; II. The Activin/BMP Receptor System; III. Design of Chimeras; IV. Assessment of Binding and Biological Properties of Chimeras; V. Summary, Conclusions, and Future Directions; Acknowledgments; References
Chapter 7: Activins and Cell MigrationI. Introduction; II. Molecular Mechanism of Activin Signaling Regulated Cell Migration; III. The Role of Activins in the Regulation of Tumor Cell Migration and Metastasis; IV. The Role of Activins in the Modulation of Immune Cell Migration; V. Conclusion and Future Prospective; Acknowledgments; References; Chapter 8: The Synthesis and Secretion of Inhibins; I. Introduction; II. Inhibin Expression and Regulation; III. Expression Profile of Inhibin in Human Tissues; IV. Inhibin Assembly; V. Circulating Inhibin Forms; VI. Concluding Remarks; References
Chapter 9: Multifunctional Roles of Activins in the BrainI. Introduction; II. Expression Pattern of Activin and Activin Receptor in the Brain; III. Activin Receptor and its Regulatory Proteins; IV. Functions of Activins in the CNS; V. Conclusion and Perspectives; Acknowledgments; References; Chapter 10: The Role of Activin/Nodal and Wnt Signaling in Endoderm Formation; I. Introduction; II. TGFbeta Signaling; III. WNT/beta-Catenin Signaling; IV. Applied Biology; V. Conclusions; Acknowledgments; References; Chapter 11: Activin in Glucose Metabolism; I. Introduction
Abstract:
First published in 1943, Vitamins and Hormones is the longest-running serial published by Academic Press. The Editorial Board now reflects expertise in the field of hormone action, vitamin action, X-ray crystal structure, physiology, and enzyme mechanisms. Under the capable and qualified editorial leadership of Dr. Gerald Litwack, Vitamins and Hormones continues to publish cutting-edge reviews of interest to endocrinologists, biochemists, nutritionists, pharmacologists, cell biologists, and molecular biologists. Others interested in the structure and function of biologically active molecules like hormones and vitamins will, as always, turn to this series for comprehensive reviews by leading contributors to this and related disciplines. This volume focuses on activins and inhibins.
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Electronic Access:
ScienceDirect http://www.sciencedirect.com/science/book/9780123859617Available:*
Shelf Number | Item Barcode | Shelf Location | Status |
|---|---|---|---|
| QP572 .I47 A27 2011 EB | 1183918-1001 | Elsevier E-Book Collections | Searching... |
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