Cover -- Front Cover -- Wnt Signaling in Embryonic Development -- Copyright Page -- Contents -- List of Contributors -- Preface -- Common principles and species differences -- Processes involved -- Pathway or network: Variations of different steps in signal transduction -- Looking ahead -- Chapter 1: Wnt/beta-catenin-mediated transcriptional regulation -- 1. Introduction -- 2. The TCF family as mediators of Wnt/beta-catenin signaling -- 3. The "Off state": Repression of Wnt targets in the absence of signaling -- 4. The "On State" in the nucleus; Arm/beta-catenin triggers the switch -- 5. beta-Catenin-mediated gene repression -- 6. Switching off signaling: A nuclear role for the destruction complex -- 7. Concluding remarks -- References -- Chapter 2: Wnt signaling and the establishment of cell polarity -- 1. Wnt-signaling pathways -- 2. Apical-basal and Planar Cell Polarity -- 3. Regulation of apical-basal polarity by Wnt signaling -- 4. PCP signaling in the Drosophila wing -- 5. PCP signaling in the Drosophila eye -- 6. PCP signaling is conserved in mammalian epithelium -- 7. Noncanonical Wnt signaling and polarized cell movements -- 8. Wnt signaling and asymmetric cell division -- 9. A new model system for PCP -- 10. Future directions -- References -- Chapter 3: Wnt signaling in C. elegans: New insights into the regulation of POP-1/TCF-mediated activation and repression -- 1. Introduction -- 2. Wnt signaling in C. elegans: Pathway components -- 3. A canonical Wnt pathway regulates Hox gene expression -- 4. Wnt/MAPK signaling -- 5. P2/EMS signaling: Spindle orientation and endoderm induction -- 6. T cell polarity -- 7. Z1/4 polarity: Axis determination in the somatic gonad -- 8. Multiple mechanisms regulate POP-1 transcriptional activity -- References -- Chapter 4: The Wnt-signaling pathways in mammalian patterning and morphogenesis -- 1. Introduction -- 2. The canonical Wnt pathway in mammalian patterning -- 3. The noncanonical Wnt pathway in mammalian morphogenesis -- 4. Summary -- References -- Chapter 5: Cell migration under control of Wnt-signaling in the vertebrate embryo -- 1. Introduction -- 2. Modes of cell migration in the vertebrate embryo -- 3. Cell migration in the early embryo -- 4. Neuronal migration -- 5. Cell migration in eye development -- 6. Heart development -- 7. Conclusions -- Acknowledgments -- References -- Chapter 6: Multiple roles for Wnt signaling in the development of the vertebrate neural crest -- 1. Introduction -- 2. Wnt signals and neural crest induction -- 3. Expression of Wnt ligands and receptors -- 4. Gain- and loss-of-function studies -- 5. Wnt signals and a hierarchy of regulatory steps -- 6. Wnt signals in delamination and the onset of migration -- 7. Wnt signals and neural crest cell fate diversification -- 8. Conclusions and future directions -- Acknowledgments -- References -- Chapter 7: Wnt pathways in angiogenesis -- 1. Angiogenesis: A brief introduction -- 2. Wnts and Frizzleds in vascular biology -- 3. Wnt signaling and pathological angiogenesis.