Cover -- Respiratory Syncytial Virus -- Copyright Page -- Contents -- Preface -- Molecular Biology of Human Respiratory Syncytial Virus -- Introduction -- The virion -- The infectious cycle -- Experimental systems to study the replicative cycle of HRSV -- Virus entry -- Transcription and replication of the viral genome -- Virus assembly -- Virus-host cell interactions -- Acknowledgements -- References -- Immunology of RSV -- The innate immune response -- The adaptive immune response -- Conclusions -- References -- Molecular Epidemiology and Evolution of RSV -- Introduction -- RSV groups and genotypes -- Structure of epidemics -- Geographic distribution of RSV strains -- The G protein -- Evolution of RSV -- Emergence of new lineages -- Disappearance of lineages -- Mechanism of selection of new strains -- Paradox -- Reinfection with RSV -- Conclusions -- References -- Genetic Susceptibility to RSV Disease -- Epidemiological evidence of genetic susceptibility to RSV infection in infancy -- Evidence that the host response rather than the virus is responsible for disease -- Requirements for effective genetic association studies -- Genetic association studies of RSV bronchiolitis -- Other studies -- General comments -- The future -- References -- Pathogenesis of RSV in Children -- Introduction -- Viral infection and cytotoxicity -- The immune response to infection -- Conclusion -- References -- RSV Infection in Elderly Adults -- Introduction -- Epidemiology -- Clinical manifestations and complications of RSV infection in elderly adults -- Diagnosis of RSV infection -- Treatment of RSV infection -- Prevention of RSV infection -- Conclusions -- References -- Respiratory Syncytial Virus Disease Burden in the Developing World -- Introduction -- Methods, definitions, limitations -- Denominator-based data on incidence -- Associated mortality -- Disease-causing agent or benign co-infection -- Risk factors for RSV infection -- Additional burdens of disease -- Temporal dynamics of RSV: Where and how does it persist -- Conclusions and future research needs -- Abbreviations -- References -- Vaccines against Human Respiratory Syncytial Virus -- Introduction: the burden of disease and the need for a vaccine -- Considerations in developing an RSV vaccine -- Formalin-inactivated RSV (FI-RSV) -- Subunit vaccines -- Live-attenuated RSV strains -- Live-vectored RSV vaccines -- DNA vaccines -- Perspective -- Acknowledgment -- References -- Development of Antivirals against Respiratory Syncytial Virus -- Introduction -- Slow progress -- Vaccines versus antivirals -- Brief history of RSV antiviral development -- Modern approaches to antiviral discovery -- Models of RSV disease -- Alternative model of human RSV in tissue culture -- Clinical trials of RSV agents -- Drugs in development -- Miscellaneous (unknown) mechanisms -- Inhibiting host cell functions -- Antisense compounds and siRNA -- Future prospects -- Acknowledgements -- References -- Pneumonia Virus of Mice -- The natural history of PVM -- Characteristics of the PVM virion -- The molecular biology of PVM -- PVM proteins -- Pathogenesis of PVM infection in inbred strains of mice: basic biology -- Explorations with the PVM infection model: therapeutic directions -- References.