Mims' Pathogenesis of Infectious Disease is the landmark book in the field of infectious disease. The new, revised edition of this work provides a comprehensive, up-to-date description of the mechanisms of microbial infection and the pathogenesis of infectious disease. Presented in a clear, accessible style, it deals in an integrated manner with the spectrum of microorganisms, describing the factors common to all infectious diseases. Molecular biology, pathology, and immunology are brought together to explain the mechanisms for spread, immune response, and recovery. Key features and of the 5th edition include: * Microbial gene sequencing * Up-to-date picture of the global burden of infectious diseases * Role of bacterial virulence factors in vivo, as contrasted with possibilities based on in vitro evidence * Latest data on combination vaccines, the promise of edible vaccines * The spread of antibiotic resistance genes among bacteria * HIV1 and HIV2; molecular biology, pathogenesis and origin * Latest data on tuberculosis - the number one infectious disease worldwide * Recent work on papillomaviruses, herpesviruses, BSE and variant CJD * Latest data on microbial evasion of immune defences * Origin and molecular biology of pandemic influenza * Significance of toxins * An update on vaccines, prions, immune evasion, microbial ligands and receptors.