TRAIL (TNF-related apoptosis-inducing ligands)
Title:
TRAIL (TNF-related apoptosis-inducing ligands)
Author:
Litwack, Gerald.
ISBN:
9780080522876
9780127098678
Publication Information:
San Diego ; London : Elsevier Academic, ©2004.
Physical Description:
1 online resource (xxiv, 496 pages) : illustrations
Series:
Vitamins and hormones : advances in research and applications ; v. 67
Vitamins and hormones ; v. 67.
Contents:
Chapter 1. Specificity of Molecular Recognition Learned from the Crystal Structures of TRAIL and the TRAIL:sDR5 Complex -- Chapter 2. Crystal Structure of RANK Ligand Involved in Bone Metabolism -- Chapter 3. Promoter of TRAIL-R2 Gene -- Chapter 4. Transcriptional Regulation of the TRAIL-R3 Gene -- Chapter 5. Monoclonal Antibodies Against TRAIL -- Chapter 6. Modulation of TRAIL Signaling Complex -- Chapter 7. TRAIL and NF kB Signaling-A Complex Relationship -- Chapter 8. CARDINAL Roles in Apoptosis and NFkB Activation -- Chapter 9. TRAIL in the Airways -- Chapter 10. TRAIL Death Receptors, Bcl-2 Protein Family, and Endoplasmic Reticulum Calcium Pool -- Chapter 11. FLIP Protein and TRAIL-Induced Apoptosis -- Chapter 12. Epidermal Growth Factor and TRAIL Interactions in Epithelial-Derived Cells -- Chapter 13. TRAIL and Ceramide -- Chapter 14. TRAIL and Viral Infection -- Chapter 15. Modulation of TRAIL Signaling for Cancer Therapy -- Chapter 16. Interferon-Gamma and TRAIL in Human Breast Tumor Cells -- Chapter 17. Retinoids and TRAIL: Two Cooperating Actors to Fight Against Cancer -- Chapter 18. Potential for TRAIL as a Therapeutic Agent in Ovarian Cancer -- Chapter 19. TRAIL and Chemotherapeutic Drugs in Cancer Therapy -- Chapter 20. Additive Effects of TRAIL and Paclitaxel on Cancer Cells: Implications for Advances in Cancer Therapy -- Chapter 21. Regulation of Sensitivity to TRAIL by the PTEN Tumor Suppressor -- Chapter 22. TRAIL and Malignant Glioma -- Chapter 23. Regulation of TRAIL-Induced Apoptosis by Ectopic Expression of Antiapoptotic Factors.
Abstract:
The discovery of TRAIL (TNF Related Apoptosis Inducing Ligand), also referred to as Apo-2, is in an era of intense research because TRAIL induces many cancer cells to undergo programmed cell death (apoptosis), while having no effect on normal cells. This important protein deserves extensive review at a formative time in the devlopement of our knowledge concerning its mechanism of action and the ways in which it can be used as a cancer chemotherapeutic agent. Consequently, this voume reviews the current status of research on TRAIL.
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Electronic Access:
ScienceDirect https://www.sciencedirect.com/science/book/9780127098678 ScienceDirect https://www.sciencedirect.com/science/bookseries/00836729/67Available:*
Shelf Number | Item Barcode | Shelf Location | Status |
|---|---|---|---|
| QP771 .V58 EB VOL. 67 | 1188663-1001 | Elsevier E-Book Collections | Searching... |
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