Front Cover; ADVANCES IN Immunology; Copyright Page; CONTENTS; Contributors; Chapter 1. MIC Genes: From Genetics to Biology; I. Introduction; II. Genes and Genomics; III. Transcripts and Transcription; IV. Biochemistry and Biology; V. Genetics and Immunogenetics; VI. Conclusion; References; Chapter 2. CD40-Mediated Regulation of Immune Responses by TRAFDependentand TRAF-Independent Signaling Mechanisms; I. Introduction; II. Discovery of CD40 and CD154; III. Functional Outcomes of CD154-CD40 Signaling; IV. Regulation of CD40 and CD154 Expression

V. Role of CD40-Induced Signaling Cascades in Functional Responses of B CellsVI. Conclusion; References; Chapter 3. Cell Death Control in Lymphocytes; I. Introduction; II. Apoptosis and the Role of Caspases; III. Apoptosis Signaling by Death Receptors; IV. Apoptosis Signaling through Apaf-1 and Caspase 9; V. Apoptosis and Its Regulation by Members of the Bcl-2 Family; VI. Transcriptional and Posttranslational Control of Bcl-2 Family Members; VII. Apoptosis and the Immune System; VIII. T Cell Development-Apoptosis at the Pre-TCR Checkpoint

IX. Positive and Negative Selection at the Pre-T Stage of DevelopmentX. T Cell Apoptosis in Peripheral Lymphoid Organs; XI. The TNF-R Family and T Cell Proliferation; XII. B Cell Development-Apoptosis at the Pre-BCR Checkpoint; XIII. Selection of Immature B Cells in the Bone Marrow; XIV. B Cell Apoptosis in Peripheral Lymphoid Organs; XV. Conclusion; References; Chapter 4. Systemic Lupus Erythematosus, Complement Deficiency, and Apoptosis; I. Introduction; II. Description of the Associations between Complement and SLE in Humans; III. Animal Models of Complement De.ciency

VI. Integration of Lipid-Protein Interactions and Calcium FluxVII. From Lipid Signaling to Protein Serine-Threonine Protein Kinases; VIII. Lipid Rafts; IX. Conclusion; References; Index; Contetns of Recent Volumes