Front Cover; Advances in Immunology, Volume 44; Copyright Page; Contents; Chapter 1. Diversity of the Immunoglobulin Gene Superfamily; I. Introduction; II. The Immunoglobulin Homology Unit and the IgGSF; III. Receptors of Immune Recognition; IV. Gene Organization and Diversity of the Major Histocompatibility Complex; V. Nonimmune Receptor Members of the IgGSF; VI. Evolution of the Immunoglobulin Gene Superfamily; References; Chapter 2. Genetically Engineered Antibody Molecules; I. Introduction; II. Antibody Production in Bacteria and Yeast; III. Gene Transfection of Lymphoid Mammalian Cells.

IV. Antibody Expression VectorsV. Cloning and Manipulating Antibody Genes; VI. Expression of Antibody Molecules; VII. Chimeric Antibody Molecules; VIII. Biological Properties of Genetically Engineered Antibodies; IX. Genetically Engineered Antigen-Combining Sites; X. Antibody Fusion Proteins; XI. Therapeutic Chimeric Antibodies; XII. Expression of Surface Immunoglobulin; XIII. Conclusions and Perspectives; References; Note Added in Proof; Chapter 3. Antinuclear Antibodies: Diagnostic Markers for Autoimmune Diseases and Probes for Cell Biology; I. Introduction.

II. Systemic Lupus Erythematosus (SLE)III. Drug-Induced Autoimmunity; IV. Mixed Connective Tissue Disease; V. Sjögren's Syndrome; VI. Dermatomyositis and Polymyositis; VII. Scleroderma; VIII. Autoantibodies of Rare Occurrence or Uncertain Disease Association; IX. Functions of Some Autoantigens; X. Molecular Cloning of Autoantigens; XI. The Autoimmune Response-A Hypothesis; XII. Clinical and Biological Significance of the New Biology of Autoantibodies; References; Chapter 4. Interleukin-1 and Its Biologically Related Cytokines; I. Introduction; II. Interleukin-1 Structure.

III. Gene Expression, Synthesis, and Processing of IL-1IV. The Biological Effects of IL-1; V. Systemic versus Local Effects of IL-1; VI. Effect of IL-1 on Immunocompetent Cells; VII. The IL-1 Receptor; VIII. Comparison of IL-1, TNF, and IL-6; IX. IL-1 and Related Cytokines in Human Disease; References; Chapter 5. Molecular and Cellular Events of T Cell Development; I. Introduction; II. T Cell Surface Molecules Involved in Antigen Recognition; III. T Cell Ontogeny Studies; IV. Function and Lineage Relations of the Major Thymocyte Subpopulations.

V. Mechanisms of Cellular Selection within the ThymusVI. Conclusions and Frontiers; References; Chapter 6. Molecular Biology and Function of CD4 and CD8; I. Introduction; II. Molecular Biology of CD8; III. Molecular Biology of CD4; IV. Summary and Discussion; References; Chapter 7. Lymphocyte Homing; I. Introduction; II. General Description of Lymphocyte-HEV Interaction; III. Regional Specificity of Lymphocyte Homing; IV. Molecules Involved in Lymphocyte Attachment to HEV; V. Involvement of Carbohydrates in Lymphocyte-HEV Interactions; References; Index; Contents of Recent Volumes.