Front Cover; Advances in Immunology, Volume 41; Copyright Page; Content; Chapter 1. Cell Surface Molecules and Early Events Involved in Human T Lymphocyte Activation; I. Introduction; II. Cell Surface Molecules Involved in T Cell Activation; III. Synergy between Ca2+ Ionophores and Phorbol Esters in T Cell Activation; IV. Receptor-Mediated Signal Transduction during T Cell Activation; V. Role of Intracellular Signals Other Than Ca2+ and pkC; VI. Effects of Early T Cell Activation Events upon Gene Regulation; VII. Summary; References.

Chapter 2. Function and Specificity of T Cell Subsets in the MouseI. Introduction; II. Cell Surface Molecules Controlling T Cell Specificity and Function; III. H-2-Restricted Recognition of Antigen by Mature T Cells; IV. Recognition of H-2 Alloantigens by Mature T Cells; V. Consequences of T Cell Contact with H-2 Molecules in the Thymus; VI. Summary; References; Chapter 3. Determinants on Major Histocompatibility Complex Class I Molecules Recognized by Cytotoxic T Lymphocytes; I. Introduction; II. Exon Shuffling to Produce Domaion Shuffled Milecules.

III. Recognition of HLA Class I Antigens on Transfected CellIV. Role of Carbohydrate Moieties in Determining CTL Recognition of Class I Molecules; V. Role of ß2-Microglobulin in T Cell Recognition of Class I Molecules; VI. Use of Monoclonal Antibodies to Block CTL Recognition of Class I Molecules; VII. Class I Heavy Chains Bearing Defined Amino Acid Changes: Effect on Polymorphic Determinants Recognized by CTL; VIII. CTL Recognition of Monoclonal Antibody-Selected Somatic Cell Class I; IX. Concluding Remarks; References; Chapter 4. Experimental Models for Understanding B Lymphocyte Formation.

I. An Introductory OverviewII. Organization of Lymphohemopoietic Tissues; III. Resolution of B Cell Precursors; IV. Rearrangement and Utilization of Immunoglobullin Genes; V. Population Dynamics; VI. Long-Term Bone Marrow Cultures; VII. An Inducible Cell Line; VIII. Some Genetically Determited Defects; IX. Soluble Mediators; X. Synthesis and Conclusions; References; Chapter 5. Cellular and Humoral Mechanisms of Cytotoxicity: Structural and Functional Analogies; I. Introduction; II. Nature of Cytotoxicity Mediated by CTL and NK Cells.

III. Cytolytic Mechanisms Proposed in the Past and the Concept of Secretion and Colloid Osmotic LysisIV. Granule Proteins in Cell-Mediated Killing; V. Membrane Attack Complex of Complemen; VI. Other Cytolytic Pore-Forming Proteins; VII. Conclusion; References; Chapter 6. Biology and Genetics of Hybrid Resistance; I. Introduction; II. Hybrid Resistance to Normal Hemopoietic Cells; III. Hybrid Resistance to Leukemia/Lymphoma Cells; IV. Effector Mechanisms of Hybrid Resistance; V. Genetics of Antigen Expression; VI. Proposed Mechanisms of Antigens Expression and Machanism of Rejection.