Front Cover; Advances in Immunology, Volume 36; Copyright Page; Contents; Contributors; Preface; Chapter 1. Antibodies of Predetermined Specificity in Biology and Medicine; I. Introduction; II. The Nature of Immunogen Determinants of Intact Proteins; III. The Loop of Lysozyme Experiments; IV. On the Number of Antigenic Determinants in Proteins; V. Antibodies of Predetermined Specificity; VI. Detection of the Products of Nucleotide Sequences; VII. Sets of Antibodies and Antibodies to Protein Domains; VIII. Structure-Function Studies.

IX. Antibodies to Proteins Encoded by Alternative Reading FramesX. Exon Usage; XI. The Chemistry of Virus Neutralization; XII. Synthetic Immunogens Representing Idiotypes, Allotypes, and Growth Factors; XIII. The Structure of an Antigenic Determinant in a Protein; XIV. Technical Aspects: The Only Rule Is That There Is No Rule; XV. Theoretical Aspects; XVI. The Repertoire Should Be Tapped Further: Concept of Immunological Catalysis; XVII. Antibody Template Directed Organic Synthesis; References; Chapter 2. A Molecular Analysis of the Cytolytic Lymphocyte Response; I. Introduction.

II. Specificity of the CTL ResponseIII. The Use of Liposomes to Study the Generation of the CTL Response; IV. The Use of Liposomes to Study the Helper T Cell Pathway; V. The Use of DNA-Mediated Gene Transfer of Cloned MHC Genes to Study CTL Specificity; VI. The Use of Monoclonal Antibodies to Define Functional CTL Antigens; VII. Conclusions; References; Chapter 3. The Human Thymic Microenvironment; I. Introduction; II. Anatomy and Histology of the Thymic Microenvironment; III. Evidence for the Participation of the Thymic Microenvironment in Promoting T Cell Maturation.

IV. Heteroantisera and Other Markers That Define Components of the Human Thymic MicroenvironmentV. Monoclonal Antibodies That Define Components of the Human and Rodent Thymic Microenvironment; VI. Ontogeny of the Human Thymus Microenvironment; VII. The Human Thymic Microenvironment in Diseases of Abnormal T Cell Maturation; VIII. Summary; References; Chapter 4. Aging, Idiotype Repertoire Shifts, and Compartmentalization of the Mucosal-Associated Lymphoid System; I. Introduction; II. Aging in the Immune System; III. Changes in the Expression of Available and Functional Repertoires.

IV. Compartmentalization of the Mucosal Immune System with AgeReferences; Chapter 5. A Major Role of the Macrophage in Quantitative Genetic Regulation of Immunoresponsiveness and Antiinfectious Immunity; I. Introduction; II. Genetic Regulation of Immunoresponsiveness; III. Modifications of Macrophage Functions; IV. Cell-Mediated Immunity in High and Low Antibody Responder Lines; V. Modifications of Innate and Immune Resistance to Infections in High and Low Antibody Responder Lines; VI. Considerations on the Genetic Control of Antiinfectious Immunity; VII. Conclusion; References; Index.