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Advances in immunology. Volume 60
Title:
Advances in immunology. Volume 60
Author:
Dixon, Frank J. (Frank James), 1920-2008.
ISBN:
9780080578361
9780120224609
Publication Information:
New York : Academic Press, ©1995.
Physical Description:
1 online resource (x, 388 pages) : illustrations.
Series:
Advances in Immunology ; v.60
Advances in immunology.
Contents:
Front Cover; Advances in Immunology, Volume 60; Copyright Page; Contents; Contributors; Chapter 1. The Janus Protein Tyrosine Kinase Family and Its Role in Cytokine Signaling; I. Introduction; II. Origins and Structure of the Janus Kinases; III. Janus Kinases Couple Cytokine Binding to Induction of Tyrosine Phosphorylation; IV. The Role of Receptor Dimerization/Oligomerization in Activation of Janus Kinases; V. Association of Jaks with Cytokine Receptors Occurs through the Membrane Proximal Domains; VI. Activation of the ras Signaling Pathway by Cytokine Receptors.
VII. Cytokines Induce Increases in Phosphatidylinositol (PI)-3 Kinase ActivityVIII. Insulin-Receptor Substitute 1 (IRS-1) and 4PS: Signal Transducers Phosphorylated in Response to Cytokines; IX. Vav: A Common Substrate of Cytokine-Induced Tyrosine Phosphorylation; X. Signal Transducers and Activators of Transcription Stats: A Novel Family of Transcription Factors Identified in Interferon Signaling; XI. Stats: A Common Theme in Cytokine Signding; XII. Mechanisms of Stat Recruitment to Cytokine Receptor Complexes; XIII. Stat Proteins Regulate a Variety of Genes in Hematopietic Cells.
XIV. Negative Regulation of Cytokine Signaling by Tyrosine PhosphatasesXV. Jaks and Stats in Other Receptor Systems; XVI. Summary and Conclusions; References; Chapter 2. X-Linked Agammaglobulinemia and Immunoglobulin Deficiency with Normal or Elevated IgM: Immunodeficiencies of B Cell Development and Differentiation; I. Introduction; II. B Cell Development and Differentiation; III. XLA: A Defect of B Cell Development; IV. HIGMX-1: A Defect of B Cell Differentiation; V. Conclusion and Future Prospects; References.
Chapter 3. Defective Glycosyl Phosphatidylinositol Anchor Synthesis and Paroxysmal Nocturnal HemoglobinuriaI. Introduction; II. The GPI Anchor and the GPI-Anchored Proteins; III. Paroxysmal Nocturnal Hemoglobinuria (PNH); IV. Perspectives and Conclusions; References; Chapter 4. The Use of Multiple Antigen Peptides in the Analysis and Induction of Protective Immune Responses against Infectious Diseases; I. Multiple Antigen Peptides; II. MAPs as Immunogens in Protozoan Diseases; III. MAPS as Immunogens in Helminthic Diseases; IV. MAPS as Immunogens in Viral and Bacterial Diseases.
V. MAPs as AntigensVI. Conclusions; References; Chapter 5. Eosinophils: Biology and Role in Disease; I. Biology of the Eosinophil; II. Eosinophils and Parasites; III. Eosinophils and Disease; IV. Final Conclusions; References; Chapter 6. In Situ Studies of the Germinal Center Reaction; I. Introduction; II. Histology of the Spleen; III. The Germinal Center Reaction; IV. Somatic Hypermutation, Selection, and the Generation of Immunological Memory; V. Germinal Centers and Other Microenvironments for Diversification; VI. Conclusions; References.
Abstract:
This volume highlights the latest reviews of mechanisms and actions of the immune system and the host response to infection and inflammation. Key Features * Covers cytokine functioning as influenced by the Janus protein tyrosine kinase family * Explores immunodeficiencies, including: * Immunoglobulin deficiencies and B cells development * Glycosyl Phosphatidylinositol (GPI)-anchor and Paroxysmal Nocturnal Hemoglobinuria (PNH) * Investigates the links molecular pathology established between deficiencies in GPI-anchor synthesis and PNH * Includes the use of Multiple Antigen Peptides (MAPs) to induce protective immune response * Offers a timely update on Eosinophils' role in disease * Covers histology of Germinal center reaction of a spleen twelve days after primary immunization * Includes new research on cytotoxic T-lymphocytes * Presents the multiple roles of Nitric oxide (NO) in the inflammatory response.
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Electronic Access:
to access electronic resource MacEwan University Access (Unlimited Concurrent Users) from ScienceDirect ScienceDirect http://www.sciencedirect.com/science/book/9780120224609Available:*
Shelf Number | Item Barcode | Shelf Location | Status |
|---|---|---|---|
| QR181 .A38 EB VOL. 60 | 1190454-1001 | Elsevier E-Book Collections | Searching... |
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