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Autophagy in disease and clinical applications. Part C
Title:
Autophagy in disease and clinical applications. Part C
Author:
Klionsky, Daniel J.
ISBN:
9780123749369
9780080958484
Publication Information:
San Diego, Calif. : Academic Press/Elsevier, 2009.
Physical Description:
1 online resource (xlix, 481 pages, 16 unnumbered pages of plates) : illustrations (some color)
Series:
Methods in enzymology, v. 453
Methods in enzymology ; v. 453.
General Note:
Called Part C in continuation of: Part A issued as volume 451 of Methods in enzymology under title: Autophagy : Lower eukaryotes and non-mammalian species, Part A; and: Part B issued as volume 452 of Methods in enzymology under title: Autophagy in mammalian systems, Part B.
Contents:
Initiation of autophagy by photodynamic therapy / David Kessel and Nancy L. Oleinick -- Autophagic cell death / Michael J. Lenardo, Christina K. McPhee, Li Yu -- Autophagic neuron death / Yasuo Uchiyama [and others] -- Assessing metabolic stress and autophagy status in epithelial tumors / Robin Mathew, Vassiliki Karantza-Wadsworth, and Eileen White -- Autophagic clearance of aggregate-prone proteins associated with neurodegeneration / Sovan Sarkar, Brinda Ravikumar, and David C. Rubinsztein -- Monitoring autophagy in Alzheimer's disease and related neurodegenerative diseases / Dun-Sheng Yang, Ju-Hyun Lee, and Ralph A. Nixon -- Live-Cell imaging of autophagy induction and autophagosome-lysosome fusion in primary cultured neurons / Mona Bains and Kim A. Heidenreich -- Using genetic mouse models to study the biology and pathology of autophagy in the central nervous system / Zhenyu Yue [and others] -- Biochemical and morphological detection of inclusion bodies in autophagy-deficient mice / Satoshi Waguri and Masaaki Komatsu -- Analyzing autophagy in clinical tissues of lung and vascular diseases / Hong Pyo Kim [and others] -- Autophagy in neurite injury and neurodegeneration : in vitro and in vivo models / Charleen T. Chu [and others] -- Monitoring the autophagy pathway in cancer / Frank C. Dorsey [and others] -- Autophagy pathways in glioblastoma / Hong Jiang [and others] -- Autophagy in lung cancer / Jerry J. Jaboin, Misun Hwang, and Bo Lu -- Signal-dependent control of autophagy-related gene expression / Fulvio Chiacchiera and Cristiano Simone -- Novel methods for measuring cardiac autophagy in vivo / Cynthia N. Perry [and others] -- Autophagy in load-induced heart disease / Hongxin Zhu, Beverly A. Rothermel, and Joseph A. Hill -- Evaluation of cell death markers in severe calcified aortic valves / Wilhelm Mistiaen and Michiel Knaapen -- Monitoring autophagy in muscle diseases / May Christine V. Malicdan, Satoru Noguchi, and Ichizo Nishino -- Analyzing macroautophagy in hepatocytes and the liver / Wen-Xing Ding and Xiao-Ming Yin -- Monitoring autophagy in lysosomal storage disorders / Nina Raben [and others].
Abstract:
The third and final installment of Daniel J. Klionsky's new three-volume treatment of autophagy, this volume focuses on monitoring autophagy with regard to disease connections, and presents methods that can be used to analyze autophagy in clinical samples. Edited by one of the leading authorities in the field, this volume and its companion volumes, Autophagy: Lower Eukaryotes and Autophagy in Mammalian Systems, provide a comprehensive overview of the techniques involved in studying autophagy in eukaryotes and simple animal systems, mammalian cells and non-human animals, and humans. Particularly in times of stress, like starvation and disease, higher organisms have an internal mechanism in their cells for chewing up and recycling parts of themselves. The process of internal "house cleaning" in the cell is called autophagy - literally self-eating. In the future, research in this field will help to design clinical approaches that can turn on autophagy and halt tumor growth. Provides an overview of autophagy in regards to humans, specifically regarding disease connections and clinical samples. Includes methods to evaluate the role of autophagy in the drug-induced cell death of cancer cells in culture, helping researchers design clinical approaches that can halt tumor growth Presents reliable methods that, in this relatively new field, allow the reader to find appropriate techniques to identify, monitor, and quantify autophagic processes.
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Electronic Access:
ScienceDirect https://www.sciencedirect.com/science/book/9780123749369 ScienceDirect https://www.sciencedirect.com/science/bookseries/00766879/453 ScienceDirect https://www.sciencedirect.com/science/bookseries/00766879 ScienceDirect http://www.sciencedirect.com/science/bookseries/00766879 ScienceDirect http://www.sciencedirect.com/science/bookseries/00766879/453Available:*
Shelf Number | Item Barcode | Shelf Location | Status |
|---|---|---|---|
| QP601 | 1190642-1001 | Elsevier E-Book Collections | Searching... |
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