RGS proteins: The early days -- Insights into RGS protein function from studies in caenorhabditis elegans -- Regulators of G protein signaling proteins as a central components of G protein-coupled receptor signaling complexes -- Structure and function of regulator of G protein signaling homology domains -- Nuclear trafficking of regulator of G protein signaling proteins and their roles in the nucleus -- Structure, function, and localization of G[beta]5-RGS complexes -- Biology and functions of the RGS9 isoforms -- The role of G[beta]5 in vision -- Regulation of immune function by G protein-coupled receptors, trimeric G proteins, and RGS proteins -- Regulators of G protein signaling in neuropsychiatric disorders -- Identification of ligands targeting RGS proteins: High-throughput screening and therapeutic protential.