Front Cover; Neonatal Clinical Pharmacology and Therapeutics; Copyright Page; Table of Contents; Contributors; Preface; Chapter 1. Pharmacological principles and kinetics; Drug-handling processes; Drug handling by the fetus; Pharmacokinetics and clinical relevance; Practical problems of drug delivery; References; Chapter 2. Placental transfer of drugs; Factors determining fetal dose; Measurement of placental transfer rate; Transfer of drugs in commonly presenting problems; Summary; References; Chapter 3. Drug therapy in pregnancy; Teratogenesis; Other effects of maternal drug therapy.

Drugs affecting the cardiovascular systemAntimicrobials; References; Chapter 4. Tocolytics and oxytocin; Tocolytics; Magnesium Sulphate; Prostaglandin Synthetase Inhibitors; Calcium channel blockers; Alcohol; Oxytocin; References; Chapter 5. Maternal drug use and neonatal withdrawal; Drugs of abuse; Drug abuse and fertility; The risks of drug abuse to the pregnant mother; The risks of drug abuse to the fetus; The management of addiction in pregnancy; The management of labour; Neonatal withdrawal syndromes; Hepatitis and HIV; Breast Feeding; The children after discharge.

The need for continuing researchReferences; Suggested further reading; Chapter 6. Prophylaxis for hyaline membrane disease; Primary prevention of prematurity; Pharmacological acceleration of lung development; References; Chapter 7. Maternal analgesia and anaesthesia and their effect on the newborn; Assessment of the neonate; Analgesia in labour; Anaesthesia; Sedatives in labour; References; Chapter 8. Treatment of neonatal apnoea; Methylxanthines: caffeine and theophylline; Doxapram; Almitrine; Other drugs; General considerations; References.

Chapter 9. Prostaglandins and the perinatal pulmonary and systemic circulationProstaglandin synthesis; The arterial duct in the preterm infant; References; Chapter 10. Treatment of cardiac disorders in the neonate; Circulatory failure; Arrhythmias; Management of SVT; References; Chapter 11. Pharmacology of antibiotics in the newborn; Pharmacology of antibiotics in the newborn; Absorption, distribution and elimination of antibiotics; Pharmacokinetics; Therapeutic implications; Conclusion; References; Chapter 12. Drugs and neonatal jaundice; Drug treatment of unconjugated hyperbilirubinaemia.

Drugs as contributors to jaundiceEffect of maternally-administered drugs; References; Chapter 13. Investigation and management of hypoglycaemia; Normal perinatal blood glucose metabolism; Hypoglycaemia; References; Chapter 14. Anticonvulsant drugs; Principles of anticonvulsant use; Drugs; References; Chapter 15. Pharmacology of vitamins A, D, E and K; Vitamin A; Vitamin D; Vitamin E (see also pp. 216-217); Vitamin K; References; Chapter 16. Oxygen transport by the blood, haematinics and blood cell component therapy in the neonate.