I Foreword II Introduction 1 Pathology of Crystal Deposition Diseases 2 Synovial Fluid Crystal Analysis 3 Purine Metabolism in the Pathogenesis of Hyperuricemia, and Inborn Errors of Purine Metabolism Associated with Disease 4 Renal Basis of Hyperuricemia 5 Pathogenesis of Tophus Formation and Gouty Inflammation 6 Gout: Epidemiology and Risk Factors 7 Genetics of Gout 8 Diagnosis of Gout 9 Clinical Features of Gout 10 Treatment of Acute Gout 11 Diet, Alcohol, Obesity, and Hyperuricemia 12 Uricosuric Therapy of Hyperuricemia in Gout 13 Xanthine Oxidase Inhibitor Treatment of Hyperuricemia 14 Uricase Therapy of Gout 15 Prophylaxis of Attacks of Acute Gouty Arthritis 16 Overview of Gout Therapy Strategy and Targets and Management of Refractory Disease 17 Quality of Care in Gout 18 Health-Related Quality of Life and Outcome Measures in Gout 19 Asymptomatic Hyperuricemia: Cardiovascular and renal Implications 20 Pathogenesis and Molecular Genetics of Calcium Pyrophosphate Dihydrate Crystal Deposition Disease 21 Clinical Features, Diagnosis, and Treatment of CPPD Crystal Arthropathy 22 Basic Calcium Phosphate Crystal Arthropathy 23 Crystalline Disorders Associated with Renal Disease Including Oxalate Arthropathy 24 Plain Radiography and Advanced Imaging of Gout 25 Plain Radiography and Advanced Imaging of CPPD and Hydroxyapatite Deposition Diseases 26 Ultrasound in the Diagnosis of Crystal Deposition Disease 27 Developing the future of diagnosis and management of gout and other crystal deposition arthropathies.