Sleeve gastrectomy (SG) is the established bariatric surgical procedure in the United States. Which baseline patient attributes influence outcomes following SG remain inconclusive. Therefore, identifying baseline predictor variables that best mediate WL success at one and two-years follow-up was investigated. Retrospective analysis of the medical records of 533 patients who underwent SG between January 1, 2014 and June 30, 2015 was completed. Follow-up included 282 subjects at one-year and 136 subjects at two-years. Chi Square and independent samples t-tests were used to compare successful and suboptimal WL groups. Multivariate logistic regression was performed to determine which variables could best predict successful WL outcome, defined as ≥ 50% excess body WL at one and two-years. The overall sample was comprised of 120 males and 413 females with a mean age of 44.73 +/- 11.9, and mean BMI of 46.9 +/- 8.1. The follow-up (n = 304) group had a significantly higher baseline BMI than the no follow-up group ( n = 229) (47.7 +/- 8.2 vs. 45.9 +/- 7.8, p = .01), otherwise the groups were similar. At one-year BMI ( p < .001) was the only independent predictor of successful WL outcome following SG. At two-years, dyslipidemia (p < .01) and smoking status (p = .047) were the only independent predictors of successful WL outcome. BMI appears to be a significant predictor variable for WL following SG. Whether other important baseline patient attributes influence successful WL following SG in the short-, mid-, and long-term warrant further investigation.