
Select an Action

Text Mining for Drug Discovery
Title:
Text Mining for Drug Discovery
Author:
Piliouras, Dimitrios, author.
Personal Author:
Physical Description:
1 electronic resource (117 pages)
General Note:
Source: Dissertation Abstracts International, Volume: 76-07C.
Abstract:
Over the last several decades, medical and biological research has risen to extraor-dinary levels, opening vast windows into the mechanisms underlying health and dis-ease in living organisms. Integrating this knowledge into a unified framework to en-hance our understanding and decision-making is a significant challenge for the researchcommunity. Efficient drug discovery and development requires methods for bridgingpre-clinical data with patient data, as well as effective literature-mining, in order to es-timate both efficacy and safety outcomes for new molecules and treatment approaches.Text mining is often regarded as an antidote to this exponential growth of biomedicalpublications.In this thesis text-mining and natural-language-processing techniques and tools,aiming to assist with various computational aspects of drug-discovery, are presented.In particular, methods useful for modelling of pharmaco-kinetic parameters, a processby which, the pharmaceutical effects of a drug can be simulated using mathematicalmodels, are pursued. In order to fully realise the potential of such modelling, there isa tremendous need for databases of verified pharmaco-kinetic/dynamic properties ofdrugs. To that end, a context-free-grammar, capable of capturing such parameters, andtheir potential modifications, is proposed. The fully deterministic nature of a contextfree grammar can be side-stepped by embedding a lexical analyser which is able toplug-in external components for specialised sub-tasks (i.e., named entity recognition).The feasibility of this approach is evaluated against a gold-standard corpus, where it isshown to be both effective and efficient, with predictive accuracy touching 90%.
Local Note:
School code: 1543
Subject Term:
Added Corporate Author:
Available:*
Shelf Number | Item Barcode | Shelf Location | Status |
|---|---|---|---|
| XX(681642.1) | 681642-1001 | Proquest E-Thesis Collection | Searching... |
On Order
Select a list
Make this your default list.
The following items were successfully added.
There was an error while adding the following items. Please try again.
:
Select An Item
Data usage warning: You will receive one text message for each title you selected.
Standard text messaging rates apply.


