Estimated placental volume (EPV), a previously validated ultrasound method of calculating the placental volume, can serve as a means to identify patients with abnormally small or large placentas. Our study aim was to validate the utility of the Vscan handheld ultrasound scanner for measuring EPV in routine prenatal examinations. Pregnant patients with singleton pregnancies presenting for routine first trimester screenings or anatomical ultrasounds were consented. The placenta was imaged at maximal width, at which point width, height and thickness were measured using a GE Voluson E8 or Philips IU22 (full-size ultrasound machines) and the GE Vscan. EPV was calculated with both machines and compared using Pearson correlation coefficient (r). Thirty patients were scanned between 11+1 and 22+3 weeks. EPVs calculated using Vscan correlated very closely to the EPVs calculated using the full-sized ultrasound devices (r=0.94, p<0.0001). The Vscan can accurately assess EPV up to approximately 20 weeks. Beyond 20 weeks the Vscan's 75-degree field-of-view may not be able to fully image a placenta with a width greater than 10 cm. In spite of this limitation, the portability and affordability of the Vscan may enable healthcare providers greater access to ultrasound technology during routine prenatal care, increasing the chances of identifying cases of abnormal placental growth.