Individuals who identify as being LGBT are at increased odds to use substances than those who are not a part of a sexual minority. This project report focuses on the factors associated with substance use among the LGBT community, in addition to examining the efficacy of interventions and programs that address this social issue. Currently literature finds that factors associated with substance use in LGBT individuals include demographic variables, geographic variables, and LGBT cultural factors. Each of these variables speaks to the individuals experiences that individuals in the LGBT community have which may contribute to the likelihood of the substances they are using, as well as the reasons they were using them. The literature on current interventions that address substance abuse in the LGBT community was organized according to the level in which the intervention was delivered to each sample; at the micro level, the mezzo level, and macro level. Interventions and programs examined include case-management models, wed-based group models, psychoeducation group models, and gay-straight alliances. Results report that regardless of level, the efficacy of interventions and programs increased when an individual's identity was affirmed, or taken into account during treatment, through methods such as creating an affirming environment, or tailoring existing interventions for clients. This report provides with a discussion, advocacy plan, and future directions for research on this topic.