Substance use and mood disorders are the most common co-occurring psychiatric disorders, with cannabis use and depression being the most prevalent. Despite the growing body of evidence examining the relationship between depression and cannabis use, the association is still not well understood. The purpose of the present study was to determine if depressive symptom type (i.e., somatic vs. cognitive) was differentially associated with severity of past month cannabis use. Due to inconsistencies in the literature, no a priori hypothesis was made. Data for this study were obtained from the 2015 national survey sample sponsored by the Substance Abuse and Mental Health Services Administration (SAMHSA). Depression variables used for the analysis consisted of the 9 symptoms related to a diagnosis of Major Depressive in the DSM-IV. Confirmatory Factor Analyses indicated that the best fitting measurement models was a two-factor model of depression, with a 4-symptom somatic factor and a 5-symptom cognitive factor. Results of the full structural equation model indicated that neither somatic nor cognitive symptom factors significantly predicted past month cannabis use. There is a need for a better understanding of the way depressive symptoms are associated with cannabis use.