Geographically isolated wetlands (GIWs) within the southeastern U.S. Coastal Plain have been increasingly recognized for their importance in providing ecosystem services. These wetlands serve as valuable foraging and breeding habitat for wetland-dependent species, including wading birds. I quantified wading bird presence in GIWs in southwestern Georgia and determined the relative importance of factors influencing their use of these wetlands. I also examined the diet of a nesting colony of Little Blue Herons; a species experiencing population declines throughout most of the Southeast. I found that wetland-specific parameters were important factors in predicting wading bird use of GIWs, and wading birds utilized agricultural and natural wetlands differently depending on hydrological seasonality. Little Blue Herons were primarily consuming large anurans and anuran larvae, which are characteristic of agriculturally modified wetlands. The seasonal process of receding water levels in GIWs and subsequent concentration of aquatic fauna in these sites provides important food resources for nesting wading birds in this region.