The emerging pollutants (EPs) originated from our fast developing modern society possess potential threat to human health and environment. Among many sources of EPs, regular as well as abusive use of antibiotics such as amoxicillin (AMX) has gained more attentions in recent years. However, corresponding treatment plan toward EPs is still in its infancy. On the other hand, novel nanomaterial (mesoporous silica supported polymers), which possess large surface area and amendable surface characteristics, can be used as adsorbent to remove EPs such as AMX. In this study, mesoporous silica supported polymers (H +-PANI/SBA-15 and PANI/SBA-15) were synthesized and demonstrated to adsorb AMX from solutions with different initial pH values and initial concentrations. Data were collected through UV-Vis spectrometer and pH meter. The material suitable for adsorbing AMX was found to be H+-PANI/SBA-15 under initial pH around 11.0 and with final pH around 7.0. The experimental adsorption data were modeled using pseudo-second order and intraparticle diffusion models and adsorption mechanisms were discussed as well.