Front Cover; Neurotransmitters; Copyright Page; Table of Contents; Introduction; Part I: GABA: Simple Molecule With Complex Functions; Chapter 1. GABA Systems in Human Brain in Huntington's Disease and Schizophrenia; GABA RECEPTOR BINDING IN HUMAN BRAIN; GAD IN HUMAN POST-MORTEM BRAIN IN HUNTINGTON'S DISEASE AND SCHIZOPHRENIA; CONCLUSIONS; REFERENCES; Chapter 2. Stereospecific Actions of GABA Analogues; INTRODUCTION; NEURONAL RECEPTORS FOR GABA IN THE CNS; UPTAKE SYSTEMS FOR GABA IN THE CNS; CYCLOPENTANE ANALOGUES OF GABA; 'ACTIVE CONFORMATIONS' OF GABA; CONCLUSION; REFERENCES; Acknowledgement.

Chapter 3. Barbiturates, Benzodiazepines and the GABA SystemThe effects on GABA-mediated synaptic inhibition; CNS depressants and GABA release; Direct GABA-like effects of depressant drugs; Effects of depressants on responses to GABA; Effects of depressants on GABA antagonists; ACKNOWLEDGEMENTS; REFERENCES; Chapter 4. Kinetics of GABA Action at the Crayfish Neuromuscular Junction; REFERENCES; Chapter 5.A Molecular Mechanism for the Action of Benzodiazepines on GABAergic Transmission; Evidence for the interaction of BZDs with GABA mechanisms.

Mechanisms by which BZD enhances GABAergic transmissionPresence of a protein modulator of the Na+-independent GABA binding in crude synaptic membranes prepared from brain; Interaction between BZDs and the endogenous modulator of the Na+- independent high affinity site for GABA; The supramolecular nature of GABA postsynaptic receptors: identification of components; REFERENCES; Chapter 6. Toward a Rational Pharmacology of the GABA System; ABSTRACT; INTRODUCTION; IDENTIFYING GABA-RELEASING NEURONS IN THE VERTEBRATE CNS; GABA NEURONS PARTICIPATE IN NUMEROUS AND COMPLEX RELATIONS.

GABA NEURONS AND FUNCTIONAL COORDINATIONGABA ACTION AND DEACTIVATION: AGONISTS, ANTAGONISTS, AND AMPLIFIERS; STRUCTURE-ACTIVITY RELATIONS; PROPOSED COUPLED ACTION-INACTIVATION MECHANISM OF GABA FUNCTION; CONCLUDING REMARKS; REFERENCES; Part II: Interdependence of Neurotransmitter Systems in the CNS; Chapter 7. Physiology and Pharmacology of Ganglionic Synapses as Models for Central Transmission; INTRODUCTION; INTRASYNAPTIC MECHANISMS; INTERSYNAPTIC MECHANISMS; MODULATION OF GANGLIONIC TRANSMISSION BY ENDOGENOUS COMPOUNDS; CONCLUSIONS; Acknowledgment; REFERENCES.

Chapter 8. Microphysiological and Pharmacological Studies on Transmitters in the Substantia NigraGABA; REFERENCES; Chapter 9. Studies of the Interdependence of Neurotransmitter Systems by Microbiochemical Approaches; Introduction; Measurement of rates of neurotransmitter utilization as a research tool in neurochemical pharmacology; Relationship between nerve stimulation and the turnover rate of ACh and GABA in identified neuronal pathways; Studies on the dopaminergic regulation of GABAergic and cholinergic neurons fby measurements of TRACh and TRGABA in brain nuclei.