Front Cover; Dedication; Chirality in Drug Design and Synthesis; Copyright Page; Contributors; Foreword; Table of Contents; Introduction; Chapter 1. Chirality: Pharmacological Action and Drug Development; Introduction; 2 Terminology; 3 Enantioselectivity in pharmacological activity; 4 Enantioselectivity in pharmacodynamics resulting from differences in the pharmacokinetics of the enantiomers; 5 Conclusion; References; Chapter 2. Racemic Therapeutics-Problems all Along the Line; 1 Introduction; 2 Implications of chirality in bioactive agents; 3 Clinical pharmacology of racemic therapeutics

4 Ethical aspects of drug development, evaluation and use5 Non-information and disinformation in the field of chirality; 6 Racemates as drug combinations; 7 Perspectives; 8 Summary; References; Chapter 3. Chirality, Drug Metabolism and Action; 1 Introduction; 2 Stereochemistry and drug disposition; 3 Stereoselective metabolism and drug action; 4 Conclusions; References; Chapter 4. From Enzyme Mimics to Molecular Self-Assembly Processes; 1 Introduction; 2 A gift from nature; 3 Needs of enzyme mimics; 4 Serendipity yet again; 5 A chiral crown ether as a reagent

6 The same chiral crown ether as a catalyst7 Coordination through the second sphere; 8 Planned molecular self-assembly; 9 From host-guest chemistry to molecular assemblies; 10 Structure-directed synthesis; 11 The future; Acknowledgements; References; Chapter 5. Modelling of Drug-Receptor Interactions: Stereoselectivity of 5-Hydroxytryptamine and Dopamine Receptors in the Brain; 1 Introduction; 2 Interactions between L-ZGP and 8-OH DPAT; 3 Modelling of drug-receptor interactions; 4 DA D2-receptor agonists and antagonists; 5 5-HT1A-receptor agonists and antagonists; Acknowledgements; References

Chapter 6. Molecular Basis of the Activity of Antibiotics of the Vancomycin Group:Guides for Peptide-Peptide Binding1 Introduction; 2 Stereoselectivity; 3 Peptide-peptide molecular recognition; 4 Approximate binding constants estimated for simple carboxylic acids; 5 A molecular interpretation of the binding process; Acknowledgements; References; Chapter 7. Recent Developments in the Use of Enzyme-Catalysed Reactions in Organic Synthesis; 1 Introduction; 2 Recent uses of hydrolase enzymes; 3 Recent uses of oxidoreductase enzymes