Front Cover; Advance In Immunology, Volume 21; Copyright Page; Contents; List of Contributors; Preface; Chapter 1. X-Ray Diffraction Studies of Immunoglobulins; I. Introduction; II. Polypeptide Chain Structure of Immunoglobulins and Antibodies; III. Techniques of Crystallographic Analysis; IV. Results of Low-Resolution X-Ray Diffraction Studies; V. High-Resolution Studies; VI. Summary and Conclusions; References; Chapter 2. Rabbit Immunoglobulin Allotypes: Structure, Immunology, and Genetics; I. Introduction; II. Structural Correlates of Allotypic Determinants.

III. Antigenic Determinants of Rabbit AllotypesIV. Genetic Relationships among Allotypes; V. Allotypes and the Immune Response; VI. Allotype Suppression; VII. Idiotypes and Allotypes; VIII. Conclusion; References; Chapter 3. Cyclical Production of Antibody as a Regulatory Mechanism in the Immune Response; I. Introduction; II. Cycling in the Immune Response; III. Synchrony of Appearance of Antibody-Producing Cells; IV. Conclusions; References; Chapter 4. Thymus-Independent B-Cell Induction and Paralysis; I. Introduction; II. Hypotheses for Immune B-Cell Activation.

III. Some Important Technical ConsiderationsIV. Critical Evidence Supporting the One Nonspecific Signal Hypothesis; V. Basis of Thymus Independence (Direct, Specific B-Cell Activation): Competing Concepts; VI. Molecular Basis of B-Cell Activation; VII. B-Cell Paralysis in Thymus-Independent Responses; VIII. B-Cell Induction and Paralysis by Nonpolyclonal Activator Molecules (Thymus-Dependent Antigens); IX. Concluding Remarks; References; Subject Index; Contents of Previous Volumes.